HAMAP

Accession	MF_00405
Dates	1-JUN-2001 (Created) 9-JUN-2011 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00405; [distribution of match scores in UniProtKB];[seed alignment for MF_00405]

Names

FabA

Identifier

FABA

Protein name

RecName: Full=3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; EC=4.2.1.60; AltName: Full=Beta-hydroxydecanoyl thioester dehydrase;

Gene name

fabA

FUNCTION: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP (By similarity).

CATALYTIC ACTIVITY: (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H(2)O.

CATALYTIC ACTIVITY: (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein] + H(2)O.

PATHWAY: Lipid metabolism; fatty acid biosynthesis.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the thioester dehydratase family. FabA subfamily.

Pfam	PF07977; FabA; 1;
TIGRFAMs	TIGR01749; FabA; 1;

Cytoplasm, Lyase, Lipid synthesis, Fatty acid biosynthesis.

GO:0008693; Molecular function: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity.
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: FABA_ECOLI (P0A6Q3)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		71		71		By similarity		H

Size range:	170-184 amino acids
Related UniRules:	MF_00406 (FABZ)
Template:	P0A6Q3 (FABA_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None