HAMAP rule MF_00551
General rule information
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Accession | MF_00551 |
Dates | 29-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 25) |
Name | Uridine_kinase |
Scope(s) |
Bacteria Archaea |
Template(s) | P0A8F4 (URK_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00551 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | URK |
Protein name | RecName: Full=Uridine kinase; EC=2.7.1.48; AltName: Full=Cytidine monophosphokinase; AltName: Full=Uridine monophosphokinase; |
Gene name | Name=udk; |
Comments
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CATALYTIC ACTIVITY | Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48; |
CATALYTIC ACTIVITY | Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674, ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; |
PATHWAY | Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. |
PATHWAY | Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the uridine kinase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0004849; Molecular function:uridine kinase activity |
GO:0008655; Biological process:pyrimidine-containing compound salvage |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00485; PRK; 1; |
PRINTS | PR00478; PHRIBLKINASE; 1; |
PRINTS | PR00988; URIDINKINASE; 1; |
NCBIfam | TIGR00235; Udk; 1; |
Features
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From: URK_ECOLI (P0A8F4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 15 | 22 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-[GA]-[ST]-[GAC]-[GSA]-G-K-[ST] |
Additional information
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Size range | 205-225 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |