HAMAP

Accession	MF_01671
Dates	29-SEP-2008 (Created) 17-FEB-2010 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01671; [distribution of match scores in UniProtKB];[seed alignment for MF_01671]

Names

IolG

Identifier

IOLG

Protein name

RecName: Full=Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; EC=1.1.1.18; EC=1.1.1.n6; AltName: Full=Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Short=MI 2-dehydrogenase/DCI 3-dehydrogenase;

Protein name

RecName: Full=Inositol 2-dehydrogenase; EC=1.1.1.18; AltName: Full=Myo-inositol 2-dehydrogenase; Short=MI 2-dehydrogenase;

Gene name

iolG

FUNCTION: Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively (By similarity).

FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) (By similarity).

CATALYTIC ACTIVITY: Myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.

CATALYTIC ACTIVITY: D-chiro-inositol + NAD(+) = 2,3,5/4,6-pentahydroxycyclohexanone + NADH.

PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7.

SUBUNIT: Homotetramer (By similarity).

SIMILARITY: Belongs to the gfo/idh/mocA family.

Pfam	PF01408; GFO_IDH_MocA; 1; PF02894; GFO_IDH_MocA_C; 1;

NAD, Oxidoreductase.

GO:0050112; Molecular function: inositol 2-dehydrogenase activity.
GO:0019310; Biological process: inositol catabolic process.

Size range:	329-366 amino acids
Related UniRules:	None
Template:	P26935 (IOLG_BACSU)
Scope:	Bacteria; Actinobacteria Bacteria; Firmicutes Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in ARTAT, MYCVP, SACEN
Plasmid encoded:	None