HAMAP

Accession	MF_01686
Dates	30-JAN-2009 (Created) 10-OCT-2011 (Last updated, Version 4)

Data class

Protein

Predictors

HAMAP; MF_01686; [distribution of match scores in UniProtKB];[seed alignment for MF_01686]

Names

Thymidy_synth_arch

Identifier

TYSY

Protein name

RecName: Full=Putative thymidylate synthase; Short=TS; Short=TSase; EC=2.1.1.-;

Gene name

thyA

FUNCTION: May catalyze the biosynthesis of dTMP using an unknown cosubstrate (By similarity).

PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.

PROSITE	PS00091; THYMIDYLATE_SYNTHASE; 1;
Pfam	PF00303; Thymidylat_synt; 1;
PRINTS	PR00108; THYMDSNTHASE; 1;
TIGRFAMs	TIGR03283; Thy_syn_methano; 1;

Cytoplasm, Methyltransferase, Nucleotide biosynthesis, Transferase.

GO:0004799; Molecular function: thymidylate synthase activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: TYSY_METTM (P80305)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		146		146		By similarity		C

Size range:	209-223 amino acids
Related UniRules:	MF_00008 (TYSY)
Template:	P80305 (TYSY_METTM)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Bacterial ThyA belong to a separate family (MF_00008).