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Annotation rule MF_00004
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General rule information [?]

Accession MF_00004
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 30)
Name Aden_phosphoribosyltr
Scope
Bacteria
Archaea
Template P69503 (APT_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
APT
Protein name
RecName: Full=Adenine phosphoribosyltransferase;
Short=APRT;
EC 2.4.2.7;
Gene name
apt

Comments [?]

Function Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Catalytic activity RHEA:16609: AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine
EC 2.4.2.7
Pathway Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords [?]


Gene Ontology [?]

GO:0003999; Molecular function: adenine phosphoribosyltransferase activity.
GO:0006168; Biological process: adenine salvage.
GO:0009116; Biological process: nucleoside metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;
TIGRFAMs TIGR01090; apt; 1;
PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;

Additional information [?]

Size range 150-280 amino acids
Related rules None
Fusion None