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HAMAP rule MF_00004

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General rule information [?]

Accession MF_00004
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 31)
Name Aden_phosphoribosyltr
Scope(s) Bacteria
Template(s) P69503 (APT_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00004 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier APT
Protein name RecName: Full=Adenine phosphoribosyltransferase;
Gene name Name=apt;

Comments [?]

FUNCTIONCatalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
CATALYTIC ACTIVITY Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=;
PATHWAYPurine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
SIMILARITYBelongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0003999; Molecular function:adenine phosphoribosyltransferase activity
GO:0006168; Biological process:adenine salvage
GO:0009116; Biological process:nucleoside metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;
NCBIfam TIGR01090; apt; 1;

Features [?]

Additional information [?]

Size range 150-280 amino acids
Related rules None
Fusion Nter: None Cter: None

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