HAMAP rule MF_00005

General rule information [?]

Accession	MF_00005
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 42)

Name	Arg_succ_synth_type1

Scope

Bacteria

Archaea

Templates

P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA): [Recover all]

Triggered by

HAMAP; MF_00005 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ASSY

Protein name

RecName:		Full=Argininosuccinate synthase;
		EC 6.3.4.5;
AltName:		Full=Citrulline--aspartate ligase;

Gene name

argG

Comments [?]

Catalytic activity	RHEA:10932: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) EC 6.3.4.5
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
Subunit	Homotetramer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
Ligase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00764; Arginosuc_synth; 1;
TIGRFAMs	TIGR00032; argG; 1;
PROSITE	PS00564; ARGININOSUCCIN_SYN_1; 1;
	PS00565; ARGININOSUCCIN_SYN_2; 1;

Features [?]

From: ASSY_THET8 (P59846)

Key From To Description Tag Condition FTGroup

BINDING 6 14 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

BINDING (Optional) 33 33 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 A

BINDING 84 84 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 Y

BINDING (Optional) 89 89 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 S

BINDING 114 114 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G

BINDING 116 116 /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991 T

BINDING 120 120 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 N

BINDING 120 120 /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991 N

BINDING 121 121 /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991 D

BINDING 124 124 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 R

BINDING 173 173 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 S

BINDING (Optional) 182 182 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 S

BINDING 258 258 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 E

BINDING 270 270 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 Y

Additional information [?]

Size range	390-447 amino acids
Related rules	MF_00581 (ASSY)
Fusion	None
Comments	Argininosuccinate synthase type 2 subfamily in MF_00581.

View rule in raw text format (no links)