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HAMAP rule MF_00005

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General rule information [?]

Accession MF_00005
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 42)
Name Arg_succ_synth_type1
Scope
Bacteria
Archaea
Templates P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ASSY
Protein name
RecName: Full=Argininosuccinate synthase;
EC 6.3.4.5;
AltName: Full=Citrulline--aspartate ligase;
Gene name
argG

Comments [?]

Catalytic activity RHEA:10932: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
EC 6.3.4.5
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00764; Arginosuc_synth; 1;
TIGRFAMs TIGR00032; argG; 1;
PROSITE PS00564; ARGININOSUCCIN_SYN_1; 1;
PS00565; ARGININOSUCCIN_SYN_2; 1;

Features [?]

From: ASSY_THET8 (P59846)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     6     14       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
BINDING (Optional)     33     33       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     A  
BINDING     84     84       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     Y  
BINDING (Optional)     89     89       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     S  
BINDING     114     114       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G  
BINDING     116     116       /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991     T  
BINDING     120     120       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     N  
BINDING     120     120       /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991     N  
BINDING     121     121       /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991     D  
BINDING     124     124       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     R  
BINDING     173     173       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     S  
BINDING (Optional)     182     182       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     S  
BINDING     258     258       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     E  
BINDING     270     270       /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743     Y  

Additional information [?]

Size range 390-447 amino acids
Related rules MF_00581 (ASSY)
Fusion None
Comments Argininosuccinate synthase type 2 subfamily in MF_00581.