HAMAP rule MF_00006

General rule information [?]

Accession	MF_00006
Dates	1-JUN-2001 (Created) 11-FEB-2022 (Last updated, Version 46)

Name	Arg_succ_lyase

Scope

Bacteria

Archaea

Template

P11447 (ARLY_ECOLI)

Triggered by

HAMAP; MF_00006 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ARLY

Protein name

RecName:		Full=Argininosuccinate lyase;
		Short=ASAL;
		EC 4.3.2.1;
AltName:		Full=Arginosuccinase;

Gene name

argH

Comments [?]

Catalytic activity	RHEA:24020: 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine EC 4.3.2.1
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.
Subcellular location	Cytoplasm.
Similarity	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
Lyase

Gene Ontology [?]

GO:0004056; Molecular function: argininosuccinate lyase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00206; Lyase_1; 1;
PRINTS	PR00145; ARGSUCLYASE; 1;
	PR00149; FUMRATELYASE; 1;
TIGRFAMs	TIGR00838; argH; 1;
PROSITE	PS00163; FUMARATE_LYASES; 1;

Additional information [?]

Size range	360-550 amino acids
Related rules	None
Fusion	Nter: <ATP-grasp domain>; Cter: MF_01105 (argA), <Unknown>

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