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Annotation rule MF_00012
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General rule information [?]

Accession MF_00012
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 34)
Name IlvD
Scope
Bacteria
Archaea
Template P05791 (ILVD_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ILVD
Protein name
RecName: Full=Dihydroxy-acid dehydratase;
Short=DAD;
EC 4.2.1.9;
Gene name
ilvD

Comments [?]

Catalytic activity RHEA:20936: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
EC 4.2.1.9
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster.
Pathway Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.
Similarity Belongs to the IlvD/Edd family.

Keywords [?]


Gene Ontology [?]

GO:0004160; Molecular function: dihydroxy-acid dehydratase activity.
GO:0009097; Biological process: isoleucine biosynthetic process.
GO:0009099; Biological process: valine biosynthetic process.

Cross-references [?]

Pfam PF00920; ILVD_EDD; 1;
TIGRFAMs TIGR00110; IlvD; 1;
PROSITE PS00886; ILVD_EDD_1; 1;
PS00887; ILVD_EDD_2; 1;

Features [?]

From: ILVD_ECOLI (P05791)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     122     122       Iron-sulfur (4Fe-4S)     C  
METAL     195     195       Iron-sulfur (4Fe-4S)     C  

Additional information [?]

Size range 547-629 amino acids
Related rules None
Fusion None