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Annotation rule MF_00015
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General rule information [?]

Accession MF_00015
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 42)
Name LexA
Scope
Bacteria
Templates P31080 (LEXA_BACSU); P0A7C2 (LEXA_ECOLI); Q9ZFA4 (LEXA_RHOS4): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LEXA
Protein name
RecName: Full=LexA repressor;
EC 3.4.21.88;
Gene name
lexA

Comments [?]

case <OC:Enterobacterales>
Function Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
else
Function Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
end case
Catalytic activity Reaction=Hydrolysis of Ala-|-Gly bond in repressor LexA.; EC=3.4.21.88;
Subunit Homodimer.
Similarity Belongs to the peptidase S24 family.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0004252; Molecular function: serine-type endopeptidase activity.
GO:0006281; Biological process: DNA repair.
GO:0006260; Biological process: DNA replication.
GO:0045892; Biological process: negative regulation of transcription, DNA-templated.
GO:0006974; Biological process: cellular response to DNA damage stimulus.
GO:0009432; Biological process: SOS response.

Cross-references [?]

Pfam PF01726; LexA_DNA_bind; 1;
PF00717; Peptidase_S24; 1;
PRINTS PR00726; LEXASERPTASE; 1;
TIGRFAMs TIGR00498; LexA; 1;

Features [?]

From: LEXA_ECOLI (P0A7C2)
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     28     48       H-T-H motif        
ACT_SITE     119     119       For autocatalytic cleavage activity     S  
ACT_SITE     156     156       For autocatalytic cleavage activity     K  
SITE     84     85       Cleavage; by autolysis     A-G  

Additional information [?]

Size range 192-275 amino acids
Related rules None
Fusion None