HAMAP logo
Due to maintenance work, this service will be unavailable Tuesday 16 between 06:00 and 06:30 - CEST. Apologies for the inconvenience.

HAMAP rule MF_00015

Send feedback

General rule information [?]

Accession MF_00015
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 45)
Name LexA
Scope(s) Bacteria
Template(s) P31080 (LEXA_BACSU); P0A7C2 (LEXA_ECOLI); Q9ZFA4 (LEXA_CERS4); [ Recover all ]
Triggered by HAMAP; MF_00015 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LEXA
Protein name RecName: Full=LexA repressor;
                 EC=3.4.21.88;
Gene name Name=lexA;

Comments [?]

case <OC:Enterobacterales>
FUNCTIONRepresses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
else
FUNCTIONRepresses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
end case
CATALYTIC ACTIVITY Reaction=Hydrolysis of Ala-|-Gly bond in repressor LexA.; EC=3.4.21.88;
SUBUNITHomodimer.
SIMILARITYBelongs to the peptidase S24 family.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0004252; Molecular function:serine-type endopeptidase activity
GO:0006281; Biological process:DNA repair
GO:0006260; Biological process:DNA replication
GO:0045892; Biological process:negative regulation of DNA-templated transcription
GO:0006974; Biological process:DNA damage response
GO:0009432; Biological process:SOS response

Cross-references [?]

Pfam PF01726; LexA_DNA_bind; 1;
Pfam PF00717; Peptidase_S24; 1;
PRINTS PR00726; LEXASERPTASE; 1;
NCBIfam TIGR00498; LexA; 1;

Features [?]

From: LEXA_ECOLI (P0A7C2)
Key From To Description Tag Condition FTGroup
DNA_BIND 28 48 /note="H-T-H motif"
ACT_SITE 119 119 /note="For autocatalytic cleavage activity" S
ACT_SITE 156 156 /note="For autocatalytic cleavage activity" K
SITE 84 85 /note="Cleavage; by autolysis" A-G

Additional information [?]

Size range 192-275 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)