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| Annotation rule MF_00016 |
General rule information
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| Accession | MF_00016 |
| Dates | 1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 30) |
| Name | DNA_helic_RuvB |
| Scope | Bacteria
Archaea; Methanomicrobiales |
| Templates | P0A812 (RUVB_ECOLI); Q5SL87 (RUVB_THET8): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. |
| Catalytic activity | RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12 |
| Subunit | Forms a complex with RuvA. |
| Similarity | Belongs to the RuvB family. |
Keywords
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DNA damage
DNA repair
SOS response
ATP-binding
Nucleotide-binding
DNA recombination
Hydrolase
Helicase
DNA repair
SOS response
ATP-binding
Nucleotide-binding
DNA recombination
Hydrolase
Helicase
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0009378; Molecular function: four-way junction helicase activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0009432; Biological process: SOS response.
GO:0009378; Molecular function: four-way junction helicase activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0009432; Biological process: SOS response.
Cross-references
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Features
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| From: RUVB_ECOLI (P0A812) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 62 | 69 | ATP | G-x-x-G-x-G-K-T | ||||||||
Additional information
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| Size range | 290-415 amino acids |
| Related rules | None |
| Fusion | None |