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Annotation rule MF_00020
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General rule information [?]

Accession MF_00020
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 34)
Name Acetate_kinase
Scope
Bacteria
Archaea
Templates P0A6A3 (ACKA_ECOLI); Q9WYB1 (ACKA_THEMA); P38502 (ACKA_METTE); P63411 (ACKA_SALTY); Q73T33 (ACKA_MYCPA); A0QQK1 (ACKA_MYCS2); B2HPZ3 (ACKA_MYCMM); A0QLU8 (ACKA_MYCA1): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ACKA
Protein name
RecName: Full=Acetate kinase;
EC 2.7.2.1;
AltName: Full=Acetokinase;
Gene name
ackA

Comments [?]

Function Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
Catalytic activity RHEA:11352: acetate + ATP = acetyl phosphate + ADP
EC 2.7.2.1
Cofactor Mg(2+)
Mn(2+)
Note: Mg(2+). Can also accept Mn(2+).
Pathway Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the acetokinase family.

Keywords [?]


Gene Ontology [?]

GO:0008776; Molecular function: acetate kinase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0016310; Biological process: phosphorylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00871; Acetate_kinase; 1;
PIRSF PIRSF000722; Acetate_prop_kin; 1;
PRINTS PR00471; ACETATEKNASE; 1;
TIGRFAMs TIGR00016; ackA; 1;
PROSITE PS01075; ACETATE_KINASE_1; 1;
PS01076; ACETATE_KINASE_2; 1;

Features [?]

From: ACKA_METTE (P38502)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     208     212       ATP     H-x-G-x-G  
NP_BIND (Optional)     283     285       ATP     D-x-R  
NP_BIND (Optional)     331     335       ATP     G-[IVLM]-G-E-[NH]  
ACT_SITE     148     148       Proton donor/acceptor     D  
METAL     7     7       Magnesium     N  
METAL     384     384       Magnesium     E  
BINDING (Optional)     14     14       ATP     K  
BINDING (Optional)     91     91       Substrate     R  
SITE     180     180       Transition state stabilizer     H  
SITE     241     241       Transition state stabilizer     R  

Additional information [?]

Size range 370-448 amino acids
Related rules MF_00542 (BUK); MF_01881 (TDCD supersedes the current rule); MF_01882 (PDUW supersedes the current rule)
Fusion None