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Annotation rule MF_00031
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General rule information [?]

Accession MF_00031
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 27)
Name DNA_helic_RuvA
Scope
Bacteria
Templates P0A809 (RUVA_ECOLI); P40832 (RUVA_MYCLE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RUVA
Protein name
RecName: Full=Holliday junction ATP-dependent DNA helicase RuvA;
EC 3.6.4.12;
Gene name
ruvA

Comments [?]

Function The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
Catalytic activity RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12
Subunit Forms a complex with RuvB.
Similarity Belongs to the RuvA family.

Keywords [?]

ATP-binding
Nucleotide-binding
DNA damage
DNA repair
SOS response
DNA-binding
DNA recombination
Hydrolase
Helicase

Gene Ontology [?]

GO:0009378; Molecular function: four-way junction helicase activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0009432; Biological process: SOS response.

Cross-references [?]

Pfam PF00633; HHH; 0-1;
PF07499; RuvA_C; 1;
PF01330; RuvA_N; 1;
TIGRFAMs TIGR00084; RuvA; 1;

Additional information [?]

Size range 150-250 amino acids
Related rules None
Fusion None


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