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Annotation rule MF_00033
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General rule information [?]

Accession MF_00033
Dates 1-JUN-2001 (Created)
3-NOV-2020 (Last updated, Version 45)
Name MurG
Scope
Bacteria
Template P17443 (MURG_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MURG
Protein name
RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;
EC 2.4.1.227;
AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;
Gene name
murG

Comments [?]

Function Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Catalytic activity RHEA:23192: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
EC 2.4.1.227
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the glycosyltransferase 28 family. MurG subfamily.

Keywords [?]

Cell cycle
Cell division
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Peptidoglycan synthesis
Transferase

Gene Ontology [?]

GO:0050511; Molecular function: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity.
GO:0030259; Biological process: lipid glycosylation.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF04101; Glyco_tran_28_C; 1;
PF03033; Glyco_transf_28; 1;
TIGRFAMs TIGR01133; MurG; 1;

Additional information [?]

Size range 333-441 amino acids
Related rules None
Fusion None


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