HAMAP rule MF_00033

General rule information [?]

Accession	MF_00033
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 50)
Name	MurG
Scope(s)	Bacteria
Template(s)	P17443 (MURG_ECOLI); Q9HW01 (MURG_PSEAE); [ Recover all ]
Triggered by	HAMAP; MF_00033 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MURG
Protein name	RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; EC=2.4.1.227; AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;
Gene name	Name=murG;

Comments [?]

FUNCTION	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II).
case <OC:Lactobacillales> or <OC:Staphylococcus>
CATALYTIC ACTIVITY	Reaction=Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP; Xref=Rhea:RHEA:23192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60032, ChEBI:CHEBI:60033; EC=2.4.1.227;
else
CATALYTIC ACTIVITY	Reaction=di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D- muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D- alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis- undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N- acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl- D-alanyl-D-alanine + H(+) + UDP; Xref=Rhea:RHEA:31227, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:61387, ChEBI:CHEBI:61388; EC=2.4.1.227;
end case
PATHWAY	Cell wall biogenesis; peptidoglycan biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Peripheral membrane protein; Cytoplasmic side.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
end case
SIMILARITY	Belongs to the glycosyltransferase 28 family. MurG subfamily.

Keywords [?]

Cell cycle
Cell division
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Peptidoglycan synthesis
Transferase

Gene Ontology [?]

GO:0050511; Molecular function:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity

GO:0030259; Biological process:lipid glycosylation

GO:0009252; Biological process:peptidoglycan biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF04101; Glyco_tran_28_C; 1;
Pfam	PF03033; Glyco_transf_28; 1;
NCBIfam	TIGR01133; MurG; 1;

Features [?]

From: MURG_PSEAE (Q9HW01)

Key

From

Description

Tag

Condition

FTGroup

BINDING