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Annotation rule MF_00033 |
General rule information
[?]
Accession |
MF_00033 |
Dates |
1-JUN-2001 (Created) 3-NOV-2020 (Last updated, Version 45) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;
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EC 2.4.1.227;
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AltName:
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Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;
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Function |
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). |
Catalytic activity |
RHEA:23192: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
EC 2.4.1.227
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Pathway |
Cell wall biogenesis; peptidoglycan biosynthesis. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Peripheral membrane protein. |
end case
Similarity |
Belongs to the glycosyltransferase 28 family. MurG subfamily. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0050511; Molecular function: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity.
GO:0030259; Biological process: lipid glycosylation.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Additional information
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Size range |
333-441 amino acids |
Related rules |
None |
Fusion |
None |