HAMAP rule MF_00033
General rule information
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Accession | MF_00033 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 50) |
Name | MurG |
Scope | Bacteria |
Templates | P17443 (MURG_ECOLI); Q9HW01 (MURG_PSEAE): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). |
case <OC:Lactobacillales> or <OC:Staphylococcus>
Catalytic activity | RHEA:23192: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
EC 2.4.1.227 |
else
Catalytic activity | RHEA:31227: di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP
EC 2.4.1.227 |
end case
Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
end case
Similarity | Belongs to the glycosyltransferase 28 family. MurG subfamily. |
Keywords
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Cell cycle
Cell division
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
Cell division
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0050511; Molecular function: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity.
GO:0030259; Biological process: lipid glycosylation.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0030259; Biological process: lipid glycosylation.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Features
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From: MURG_PSEAE (Q9HW01) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 12 | 14 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705 | [TS]-[GA]-G | ||||||||
BINDING (Optional) | 262 | 267 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705 | [AG]-L-[TS]-V-x-[ED] | ||||||||
BINDING (Optional) | 124 | 124 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705 | N | ||||||||
BINDING (Optional) | 163 | 163 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705 | R | ||||||||
BINDING (Optional) | 189 | 189 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705 | S | ||||||||
BINDING (Optional) | 243 | 243 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705 | I | ||||||||
BINDING (Optional) | 288 | 288 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705 | Q |
Additional information
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Size range | 333-441 amino acids |
Related rules | None |
Fusion | None |