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HAMAP rule MF_00033

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General rule information [?]

Accession MF_00033
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 50)
Name MurG
Scope
Bacteria
Templates P17443 (MURG_ECOLI); Q9HW01 (MURG_PSEAE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MURG
Protein name
RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;
EC 2.4.1.227;
AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;
Gene name
murG

Comments [?]

Function Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
case <OC:Lactobacillales> or <OC:Staphylococcus>
Catalytic activity RHEA:23192: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
EC 2.4.1.227
else
Catalytic activity RHEA:31227: di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP
EC 2.4.1.227
end case
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein; Cytoplasmic side.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
end case
Similarity Belongs to the glycosyltransferase 28 family. MurG subfamily.

Keywords [?]

Cell cycle
Cell division
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Peptidoglycan synthesis
Transferase

Gene Ontology [?]

GO:0050511; Molecular function: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity.
GO:0030259; Biological process: lipid glycosylation.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF04101; Glyco_tran_28_C; 1;
PF03033; Glyco_transf_28; 1;
NCBIfam TIGR01133; MurG; 1;

Features [?]

From: MURG_PSEAE (Q9HW01)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     12     14       /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705     [TS]-[GA]-G  
BINDING (Optional)     262     267       /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705     [AG]-L-[TS]-V-x-[ED]  
BINDING (Optional)     124     124       /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705     N  
BINDING (Optional)     163     163       /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705     R  
BINDING (Optional)     189     189       /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705     S  
BINDING (Optional)     243     243       /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705     I  
BINDING (Optional)     288     288       /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705     Q  

Additional information [?]

Size range 333-441 amino acids
Related rules None
Fusion None


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