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Annotation rule MF_00038
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General rule information [?]

Accession MF_00038
Dates 1-JUN-2001 (Created)
14-JAN-2021 (Last updated, Version 50)
Name MraY
Scope
Bacteria
Archaea
Templates P0A6W3 (MRAY_ECOLI); Q2FZ93 (MRAY_STAA8); O66465 (MRAY_AQUAE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MRAY
case <OC:Bacteria>
Protein name
RecName: Full=Phospho-N-acetylmuramoyl-pentapeptide-transferase;
EC 2.7.8.13;
AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
Gene name
mraY
else case <OC:Archaea>
Protein name
RecName: Full=Putative phospho-N-acetylmuramoyl-pentapeptide-transferase;
EC 2.7.8.13;
AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
end case

Comments [?]

case <OC:Bacteria>
Function Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
end case
case <OC:Lactobacillales> or <OC:Staphylococcus>
Catalytic activity RHEA:21920: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP
EC 2.7.8.13
else
Catalytic activity RHEA:28386: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
EC 2.7.8.13
end case
Cofactor Mg(2+)
case <OC:Bacteria>
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords [?]

case <OC:Bacteria>
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Peptidoglycan synthesis
end case
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Magnesium
Membrane
Metal-binding
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008963; Molecular function: phospho-N-acetylmuramoyl-pentapeptide-transferase activity.
case <OC:Bacteria>
GO:0009252; Biological process: peptidoglycan biosynthetic process.
end case
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00953; Glycos_transf_4; 1;
TIGRFAMs TIGR00445; MraY; 1;
PROSITE PS01347; MRAY_1; 1;
PS01348; MRAY_2; 1;

Computed features [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
General Transmembrane; -; 10; trigger=yes;
ADD_TOPO_DOMAIN Periplasmic; -; 6; trigger=yes;
Cytoplasmic; -; 5; trigger=yes;
else
General Transmembrane; -; 8-11; trigger=yes;
end case

Additional information [?]

Size range 302-422 amino acids
Related rules None
Fusion None
Comments Very divergent TREPA


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