 |
|
Annotation rule MF_00038 |
General rule information
[?]
Accession |
MF_00038 |
Dates |
1-JUN-2001 (Created) 3-NOV-2020 (Last updated, Version 49) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Bacteria>
Protein name |
RecName:
|
Full=Phospho-N-acetylmuramoyl-pentapeptide-transferase;
|
|
EC 2.7.8.13;
|
AltName:
|
Full=UDP-MurNAc-pentapeptide phosphotransferase;
|
|
else case <OC:Archaea>
Protein name |
RecName:
|
Full=Putative phospho-N-acetylmuramoyl-pentapeptide-transferase;
|
|
EC 2.7.8.13;
|
AltName:
|
Full=UDP-MurNAc-pentapeptide phosphotransferase;
|
|
end case
case <OC:Bacteria>
Function |
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan. |
end case
Catalytic activity |
RHEA:21920: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP
EC 2.7.8.13
|
case <OC:Bacteria>
Pathway |
Cell wall biogenesis; peptidoglycan biosynthesis. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity |
Belongs to the glycosyltransferase 4 family. MraY subfamily. |
case <OC:Bacteria>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0008963; Molecular function: phospho-N-acetylmuramoyl-pentapeptide-transferase activity.
case <OC:Bacteria>
GO:0009252; Biological process: peptidoglycan biosynthetic process.
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
General |
Transmembrane; -; 10; trigger=yes; |
ADD_TOPO_DOMAIN |
Periplasmic; -; 6; trigger=yes; |
|
Cytoplasmic; -; 5; trigger=yes; |
else
General |
Transmembrane; -; 8-11; trigger=yes; |
end case
Additional information
[?]
Size range |
302-422 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Very divergent TREPA |