HAMAP rule MF_00038
General rule information
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| Accession | MF_00038 |
| Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 51) |
| Name | MraY |
| Scope | Bacteria
Archaea |
| Templates | P0A6W3 (MRAY_ECOLI); Q2FZ93 (MRAY_STAA8); O66465 (MRAY_AQUAE): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
case <OC:Bacteria>
| Protein name |
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| Gene name |
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else case <OC:Archaea>
| Protein name |
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end case
Comments
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case <OC:Bacteria>
| Function | Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I. |
end case
case <OC:Lactobacillales> or <OC:Staphylococcus>
| Catalytic activity | RHEA:21920: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP
EC 2.7.8.13 |
else
| Catalytic activity | RHEA:28386: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
EC 2.7.8.13 |
end case
| Cofactor | Mg(2+) |
case <OC:Bacteria>
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the glycosyltransferase 4 family. MraY subfamily. |
Keywords
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case <OC:Bacteria>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0008963; Molecular function: phospho-N-acetylmuramoyl-pentapeptide-transferase activity.
case <OC:Bacteria>
GO:0009252; Biological process: peptidoglycan biosynthetic process.
end case
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| Pfam | PF00953; Glycos_transf_4; 1; |
| NCBIfam | TIGR00445; MraY; 1; |
| PROSITE | PS01347; MRAY_1; 1; |
| PS01348; MRAY_2; 1; |
Computed features
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case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
| General | Transmembrane; -; 10; trigger=yes; |
| ADD_TOPO_DOMAIN | Periplasmic; -; 6; trigger=yes; |
| Cytoplasmic; -; 5; trigger=yes; |
else
| General | Transmembrane; -; 8-11; trigger=yes; |
end case
Additional information
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| Size range | 302-422 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Very divergent TREPA |