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HAMAP rule MF_00038

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General rule information [?]

Accession MF_00038
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 51)
Name MraY
Scope(s) Bacteria
Template(s) P0A6W3 (MRAY_ECOLI); Q2FZ93 (MRAY_STAA8); O66465 (MRAY_AQUAE); [ Recover all ]
Triggered by HAMAP; MF_00038 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MRAY
case <OC:Bacteria>
Protein name RecName: Full=Phospho-N-acetylmuramoyl-pentapeptide-transferase;
AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
Gene name Name=mraY;
else case <OC:Archaea>
Protein name RecName: Full=Putative phospho-N-acetylmuramoyl-pentapeptide-transferase;
AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
end case

Comments [?]

case <OC:Bacteria>
FUNCTIONCatalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc- pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
end case
case <OC:Lactobacillales> or <OC:Staphylococcus>
CATALYTIC ACTIVITY Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha- D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis- undecaprenyl diphosphate + UMP; Xref=Rhea:RHEA:21920, ChEBI:CHEBI:57865, ChEBI:CHEBI:60032, ChEBI:CHEBI:60392, ChEBI:CHEBI:70758; EC=;
CATALYTIC ACTIVITY Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha- D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D- alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl- alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D- alanyl-D-alanine + UMP; Xref=Rhea:RHEA:28386, ChEBI:CHEBI:57865, ChEBI:CHEBI:60392, ChEBI:CHEBI:61386, ChEBI:CHEBI:61387; EC=;
end case
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Bacteria>
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008963; Molecular function:phospho-N-acetylmuramoyl-pentapeptide-transferase activity
case <OCellular component:Bacteria>
GO:0009252; Biological process:peptidoglycan biosynthetic process
end case
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00953; Glycos_transf_4; 1;
NCBIfam TIGR00445; MraY; 1;
PROSITE PS01347; MRAY_1; 1;
PROSITE PS01348; MRAY_2; 1;
General Transmembrane; -; 10;
ADD_TOPO_DOMAIN Periplasmic; -; 6;
ADD_TOPO_DOMAIN Cytoplasmic; -; 5;
General Transmembrane; -; 8-11;

Features [?]

Additional information [?]

Size range 302-422 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Very divergent TREPA

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