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HAMAP rule MF_00039

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General rule information [?]

Accession MF_00039
Dates 1-JUN-2001 (Created)
23-NOV-2023 (Last updated, Version 29)
Name Adenylate_kinase_AK6
Scope(s) Archaea
Template(s) Q9UZK4 (KAD6_PYRAB); Q9Y3D8 (KAD6_HUMAN); [ Recover all ]
Triggered by
case c? <OC:Archaea>
HAMAP; MF_00039 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KAD6
Protein name RecName: Full=Putative adenylate kinase;
AltName: Full=ATP-AMP transphosphorylase;

Comments [?]

FUNCTIONBroad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late maturation steps of the 30S ribosomal particles, specifically 16S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit.
CATALYTIC ACTIVITY Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITY Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
SUBUNITInteracts with uS11. Not a structural component of 40S pre- ribosomes, but transiently interacts with them by binding to uS11.
SIMILARITYBelongs to the adenylate kinase family. AK6 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004017; Molecular function:adenylate kinase activity
GO:0005524; Molecular function:ATP binding
GO:0042274; Biological process:ribosomal small subunit biogenesis

Cross-references [?]

Features [?]

Key From To Description Tag Condition FTGroup
REGION 30 50 /note="NMP"
REGION 99 109 /note="LID"
BINDING 10 10 /ligand="ATP"
BINDING 12 12 /ligand="ATP"
BINDING 13 13 /ligand="ATP"
BINDING 14 14 /ligand="ATP"
BINDING 15 15 /ligand="ATP"
BINDING 100 100 /ligand="ATP"
BINDING 138 138 /ligand="ATP"

Additional information [?]

Size range 148-196 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Has homologs in eukaryotes

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