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Annotation rule MF_00042
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General rule information [?]

Accession MF_00042
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 33)
Name RNase_H
Templates P0A7Y4 (RNH_ECOLI); P29253 (RNH_THET8): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Ribonuclease H;
Short=RNase H;
Gene name

Comments [?]

Function Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
Subunit Monomer.
Subcellular location Cytoplasm.
Similarity Belongs to the RNase H family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00075; RNase_H; 1;
PROSITE PS50879; RNASE_H; 1; trigger=PRU00408;

Features [?]

From: RNH_ECOLI (P0A7Y4)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     10     10       Magnesium 1     D  
METAL     10     10       Magnesium 2     D  
METAL     48     48       Magnesium 1     E  
METAL     70     70       Magnesium 1     D  
METAL     134     134       Magnesium 2     D  

Additional information [?]

Size range 143-231 amino acids
Related rules None
Fusion None
Comments Possible C-terminal domain in STRCO. Divergence in TREPA.