HAMAP logo

HAMAP rule MF_00042

Send feedback

General rule information [?]

Accession MF_00042
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 36)
Name RNase_H
Scope(s) Bacteria
Template(s) P0A7Y4 (RNH_ECOLI); P29253 (RNH_THET8); [ Recover all ]
Triggered by HAMAP; MF_00042 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RNH
Protein name RecName: Full=Ribonuclease H;
                 Short=RNase H;
Gene name Name=rnhA;

Comments [?]

FUNCTIONEndonuclease that specifically degrades the RNA of RNA-DNA hybrids.
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.;
SIMILARITYBelongs to the RNase H family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0004523; Molecular function:RNA-DNA hybrid ribonuclease activity
GO:0006401; Biological process:RNA catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00075; RNase_H; 1;
PROSITE PS50879; RNASE_H_1; 1;

Features [?]

From: RNH_ECOLI (P0A7Y4)
Key From To Description Tag Condition FTGroup
BINDING 10 10 /ligand="Mg(2+)"
BINDING 10 10 /ligand="Mg(2+)"
BINDING 48 48 /ligand="Mg(2+)"
BINDING 70 70 /ligand="Mg(2+)"
BINDING 134 134 /ligand="Mg(2+)"

Additional information [?]

Size range 143-231 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible C-terminal domain in STRCO. Divergence in TREPA.

View rule in raw text format (no links)