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| Annotation rule MF_00042 |
General rule information
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| Accession | MF_00042 |
| Dates | 1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 33) |
| Name | RNase_H |
| Scope | Bacteria |
| Templates | P0A7Y4 (RNH_ECOLI); P29253 (RNH_THET8): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. |
| Catalytic activity | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
| Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding. |
| Subunit | Monomer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the RNase H family. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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| From: RNH_ECOLI (P0A7Y4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| METAL | 10 | 10 | Magnesium 1 | D | ||||||||
| METAL | 10 | 10 | Magnesium 2 | D | ||||||||
| METAL | 48 | 48 | Magnesium 1 | E | ||||||||
| METAL | 70 | 70 | Magnesium 1 | D | ||||||||
| METAL | 134 | 134 | Magnesium 2 | D | ||||||||
Additional information
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| Size range | 143-231 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Possible C-terminal domain in STRCO. Divergence in TREPA. |