HAMAP rule MF_00046
General rule information
[?]
| Accession | MF_00046 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43) |
| Name | MurC |
| Scope(s) |
Bacteria |
| Template(s) | P17952 (MURC_ECOLI); Q9WY73 (MURC_THEMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00046 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | MURC |
| Protein name | RecName: Full=UDP-N-acetylmuramate--L-alanine ligase; EC=6.3.2.8; AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase; |
| Gene name | Name=murC; |
Comments
[?]
| FUNCTION | Cell wall formation. |
| CATALYTIC ACTIVITY | Reaction=ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine; Xref=Rhea:RHEA:23372, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57972, ChEBI:CHEBI:70757, ChEBI:CHEBI:83898, ChEBI:CHEBI:456216; EC=6.3.2.8; |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the MurCDEF family. |
Keywords
[?]
| ATP-binding |
| Cell cycle |
| Cell division |
| Cell shape |
| Cell wall biogenesis/degradation |
| Cytoplasm |
| Ligase |
| Nucleotide-binding |
| Peptidoglycan synthesis |
Gene Ontology
[?]
| GO:0005524; Molecular function:ATP binding |
| GO:0008763; Molecular function:UDP-N-acetylmuramate-L-alanine ligase activity |
| GO:0009252; Biological process:peptidoglycan biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Features
[?]
| From: MURC_ECOLI (P17952) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 126 | 132 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x(2)-G-K-[ST]-[STG] | ||||||||
Additional information
[?]
| Size range | 431-539 amino acids |
| Related rules |
MF_00208 |
| Fusion | Nter: None Cter: MF_00047 (ddl) |
| Comments | Weird insertion in NOSS1 and SYNY3. Probable wrong start in LACLA. |