HAMAP logo

HAMAP rule MF_00046

Send feedback

General rule information [?]

Accession MF_00046
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43)
Name MurC
Templates P17952 (MURC_ECOLI); Q9WY73 (MURC_THEMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=UDP-N-acetylmuramate--L-alanine ligase;
AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase;
Gene name

Comments [?]

Function Cell wall formation.
Catalytic activity RHEA:23372: ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location Cytoplasm.
Similarity Belongs to the MurCDEF family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0008763; Molecular function: UDP-N-acetylmuramate-L-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
PF02875; Mur_ligase_C; 1;
NCBIfam TIGR01082; MurC; 1;

Features [?]

From: MURC_ECOLI (P17952)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     126     132       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x(2)-G-K-[ST]-[STG]  

Additional information [?]

Size range 431-539 amino acids
Related rules MF_00208 (MURE)
Fusion Nter: None; Cter: MF_00047 (ddl)
Comments Weird insertion in NOSS1 and SYNY3. Probable wrong start in LACLA.