HAMAP rule MF_00046
General rule information
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| Accession | MF_00046 |
| Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 43) |
| Name | MurC |
| Scope | Bacteria |
| Templates | P17952 (MURC_ECOLI); Q9WY73 (MURC_THEMA): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Cell wall formation. |
| Catalytic activity | RHEA:23372: ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
EC 6.3.2.8 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the MurCDEF family. |
Keywords
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ATP-binding
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Nucleotide-binding
Peptidoglycan synthesis
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Nucleotide-binding
Peptidoglycan synthesis
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0008763; Molecular function: UDP-N-acetylmuramate-L-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0008763; Molecular function: UDP-N-acetylmuramate-L-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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| From: MURC_ECOLI (P17952) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 126 | 132 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x(2)-G-K-[ST]-[STG] | ||||||||
Additional information
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| Size range | 431-539 amino acids |
| Related rules | MF_00208 (MURE) |
| Fusion | Nter: None; Cter: MF_00047 (ddl) |
| Comments | Weird insertion in NOSS1 and SYNY3. Probable wrong start in LACLA. |