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HAMAP rule MF_00046

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General rule information [?]

Accession MF_00046
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43)
Name MurC
Scope(s) Bacteria
Template(s) P17952 (MURC_ECOLI); Q9WY73 (MURC_THEMA); [ Recover all ]
Triggered by HAMAP; MF_00046 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MURC
Protein name RecName: Full=UDP-N-acetylmuramate--L-alanine ligase;
AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase;
Gene name Name=murC;

Comments [?]

FUNCTIONCell wall formation.
CATALYTIC ACTIVITY Reaction=ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine; Xref=Rhea:RHEA:23372, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57972, ChEBI:CHEBI:70757, ChEBI:CHEBI:83898, ChEBI:CHEBI:456216; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
SIMILARITYBelongs to the MurCDEF family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0008763; Molecular function:UDP-N-acetylmuramate-L-alanine ligase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
Pfam PF02875; Mur_ligase_C; 1;
NCBIfam TIGR01082; MurC; 1;

Features [?]

From: MURC_ECOLI (P17952)
Key From To Description Tag Condition FTGroup
BINDING 126 132 /ligand="ATP"

Additional information [?]

Size range 431-539 amino acids
Related rules MF_00208
Fusion Nter: None Cter: MF_00047 (ddl)
Comments Weird insertion in NOSS1 and SYNY3. Probable wrong start in LACLA.

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