HAMAP rule MF_00047
General rule information
[?]
| Accession | MF_00047 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 35) |
| Name | Dala_Dala_lig |
| Scope(s) |
Bacteria |
| Template(s) | P07862 (DDLB_ECOLI); P0A6J8 (DDLA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00047 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | DDL |
| Protein name | RecName: Full=D-alanine--D-alanine ligase; EC=6.3.2.4; AltName: Full=D-Ala-D-Ala ligase; AltName: Full=D-alanylalanine synthetase; |
| Gene name | Name=ddl; |
Comments
[?]
| FUNCTION | Cell wall formation. |
| CATALYTIC ACTIVITY | Reaction=ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate; Xref=Rhea:RHEA:11224, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57416, ChEBI:CHEBI:57822, ChEBI:CHEBI:456216; EC=6.3.2.4; |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the D-alanine--D-alanine ligase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0008716; Molecular function:D-alanine-D-alanine ligase activity |
| GO:0009252; Biological process:peptidoglycan biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
| Pfam | PF07478; Dala_Dala_lig_C; 1; |
| Pfam | PF01820; Dala_Dala_lig_N; 1; |
| NCBIfam | TIGR01205; D_ala_D_alaTIGR; 1; |
| PROSITE | PS00843; DALA_DALA_LIGASE_1; 1; |
| PROSITE | PS00844; DALA_DALA_LIGASE_2; 1; |
| PROSITE | PS50975; ATP_GRASP; 1; |
Features
[?]
Additional information
[?]
| Size range | 291-396 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_00046 (murC) Cter: None |
| Comments | Short BACSU, but does not seem to be extendable |