HAMAP rule MF_00047

General rule information [?]

Accession	MF_00047
Dates	1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 34)

Name	Dala_Dala_lig

Scope

Bacteria

Templates

P07862 (DDLB_ECOLI); P0A6J8 (DDLA_ECOLI): [Recover all]

Triggered by

HAMAP; MF_00047 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DDL

Protein name

RecName:		Full=D-alanine--D-alanine ligase;
		EC 6.3.2.4;
AltName:		Full=D-Ala-D-Ala ligase;
AltName:		Full=D-alanylalanine synthetase;

Gene name

ddl

Comments [?]

Function	Cell wall formation.
Catalytic activity	RHEA:11224: ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate EC 6.3.2.4
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location	Cytoplasm.
Similarity	Belongs to the D-alanine--D-alanine ligase family.

Keywords [?]

Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Peptidoglycan synthesis

Gene Ontology [?]

GO:0008716; Molecular function: D-alanine-D-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF07478; Dala_Dala_lig_C; 1;
	PF01820; Dala_Dala_lig_N; 1;
TIGRFAMs	TIGR01205; D_ala_D_alaTIGR; 1;
PROSITE	PS00843; DALA_DALA_LIGASE_1; 1;
	PS00844; DALA_DALA_LIGASE_2; 1;
	PS50975; ATP_GRASP; 1; trigger=PRU00409;

Additional information [?]

Size range	291-396 amino acids
Related rules	None
Fusion	Nter: MF_00046 (murC); Cter: None
Comments	Short BACSU, but does not seem to be extendable

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