HAMAP rule MF_00052
General rule information
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| Accession | MF_00052 |
| Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 34) |
| Name | RNase_HII |
| Scope | Bacteria
Archaea |
| Templates | O31744 (RNH2_BACSU); P10442 (RNH2_ECOLI); O29634 (RNH2_ARCFU); Q57599 (RNH2_METJA); O74035 (RNH2_THEKO): [Recover all] |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
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| Gene name |
|
Comments
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| Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. |
| Catalytic activity | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
| Cofactor | Mn(2+) Mg(2+) Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the RNase HII family. |
Keywords
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Gene Ontology
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GO:0030145; Molecular function: manganese ion binding.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| PROSITE | PS51975; RNASE_H_2; 1; trigger=PRU01319; |
| Pfam | PF01351; RNase_HII; 1; |
| NCBIfam | TIGR00729; TIGR00729; 1; |
Features
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case <OC:Bacteria>
| From: RNH2_ECOLI (P10442) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 16 | 16 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
| BINDING | 17 | 17 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | E | ||||||||
| BINDING | 108 | 108 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
end case
case <OC:Archaea>
| From: RNH2_METJA (Q57599) | ||||||||||||
| BINDING | 7 | 7 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
| BINDING | 8 | 8 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | E | ||||||||
| BINDING | 112 | 112 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
end case
Additional information
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case <OC:Bacteria>
| Size range | 181-315 amino acids |
end case
case <OC:Archaea>
| Size range | 195-277 amino acids |
end case
| Related rules | None |
| Fusion | None |
| Comments | Divergent CAUVC not shown in alignment. Possible wrong start in a number of cases. |