HAMAP rule MF_00052
General rule information
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| Accession | MF_00052 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 34) |
| Name | RNase_HII |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O31744 (RNH2_BACSU); P10442 (RNH2_ECOLI); O29634 (RNH2_ARCFU); Q57599 (RNH2_METJA); O74035 (RNH2_THEKO); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_00052_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_00052_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RNH2 |
| Protein name | RecName: Full=Ribonuclease HII; Short=RNase HII; EC=3.1.26.4; |
| Gene name | Name=rnhB; |
Comments
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| FUNCTION | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. |
| CATALYTIC ACTIVITY | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the RNase HII family. |
Keywords
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Gene Ontology
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| GO:0030145; Molecular function:manganese ion binding |
| GO:0004523; Molecular function:RNA-DNA hybrid ribonuclease activity |
| GO:0006401; Biological process:RNA catabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: RNH2_ECOLI (P10442) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| BINDING | 16 | 16 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | ||||||||
| BINDING | 17 | 17 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
E | ||||||||
| BINDING | 108 | 108 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | ||||||||
| end case | ||||||||||||
| From: RNH2_METJA (Q57599) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Archaea> | ||||||||||||
| BINDING | 7 | 7 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | ||||||||
| BINDING | 8 | 8 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
E | ||||||||
| BINDING | 112 | 112 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 195-277 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Divergent CAUVC not shown in alignment. Possible wrong start in a number of cases. |