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HAMAP rule MF_00052

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General rule information [?]

Accession MF_00052
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 34)
Name RNase_HII
Templates O31744 (RNH2_BACSU); P10442 (RNH2_ECOLI); O29634 (RNH2_ARCFU); Q57599 (RNH2_METJA); O74035 (RNH2_THEKO): [Recover all]
case <OC:Bacteria>
end case

case <OC:Archaea>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Ribonuclease HII;
Short=RNase HII;
Gene name

Comments [?]

Function Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
Cofactor Mn(2+)
Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
Subcellular location Cytoplasm.
Similarity Belongs to the RNase HII family.

Keywords [?]

Gene Ontology [?]

GO:0030145; Molecular function: manganese ion binding.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51975; RNASE_H_2; 1; trigger=PRU01319;
Pfam PF01351; RNase_HII; 1;
NCBIfam TIGR00729; TIGR00729; 1;

Features [?]

case <OC:Bacteria>
From: RNH2_ECOLI (P10442)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     16     16       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  
BINDING     17     17       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     E  
BINDING     108     108       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  
end case
case <OC:Archaea>
From: RNH2_METJA (Q57599)
BINDING     7     7       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  
BINDING     8     8       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     E  
BINDING     112     112       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  
end case

Additional information [?]

case <OC:Bacteria>
Size range 181-315 amino acids
end case
case <OC:Archaea>
Size range 195-277 amino acids
end case
Related rules None
Fusion None
Comments Divergent CAUVC not shown in alignment. Possible wrong start in a number of cases.