HAMAP rule MF_00052
General rule information
[?]
Accession | MF_00052 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 34) |
Name | RNase_HII |
Scope | Bacteria
Archaea |
Templates | O31744 (RNH2_BACSU); P10442 (RNH2_ECOLI); O29634 (RNH2_ARCFU); Q57599 (RNH2_METJA); O74035 (RNH2_THEKO): [Recover all] |
case <OC:Bacteria>
Triggered by |
end case
case <OC:Archaea>
Triggered by |
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. |
Catalytic activity | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
Cofactor | Mn(2+) Mg(2+) Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the RNase HII family. |
Keywords
[?]
Gene Ontology
[?]
GO:0030145; Molecular function: manganese ion binding.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
[?]
PROSITE | PS51975; RNASE_H_2; 1; trigger=PRU01319; |
Pfam | PF01351; RNase_HII; 1; |
NCBIfam | TIGR00729; TIGR00729; 1; |
Features
[?]
case <OC:Bacteria>
From: RNH2_ECOLI (P10442) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 16 | 16 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
BINDING | 17 | 17 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | E | ||||||||
BINDING | 108 | 108 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D |
end case
case <OC:Archaea>
From: RNH2_METJA (Q57599) | ||||||||||||
BINDING | 7 | 7 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
BINDING | 8 | 8 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | E | ||||||||
BINDING | 112 | 112 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D |
end case
Additional information
[?]
case <OC:Bacteria>
Size range | 181-315 amino acids |
end case
case <OC:Archaea>
Size range | 195-277 amino acids |
end case
Related rules | None |
Fusion | None |
Comments | Divergent CAUVC not shown in alignment. Possible wrong start in a number of cases. |