HAMAP rule MF_00053
General rule information
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| Accession | MF_00053 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 29) |
| Name | RNase_HIII |
| Scope(s) |
Bacteria |
| Template(s) | P94541 (RNH3_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00053 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RNH3 |
| Protein name | RecName: Full=Ribonuclease HIII; Short=RNase HIII; EC=3.1.26.4; |
| Gene name | Name=rnhC; |
Comments
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| FUNCTION | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. |
| CATALYTIC ACTIVITY | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the RNase HII family. RnhC subfamily. |
Keywords
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Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0004523; Molecular function:RNA-DNA hybrid ribonuclease activity |
| GO:0006401; Biological process:RNA catabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: RNH3_BACSU (P94541) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 100 | 100 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | ||||||||
| BINDING | 101 | 101 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
E | ||||||||
| BINDING | 205 | 205 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | ||||||||
Additional information
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| Size range | 257-316 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |