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HAMAP rule MF_00053

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General rule information [?]

Accession MF_00053
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 29)
Name RNase_HIII
Template P94541 (RNH3_BACSU)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Ribonuclease HIII;
Short=RNase HIII;
Gene name

Comments [?]

Function Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
Cofactor Mn(2+)
Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
Subcellular location Cytoplasm.
Similarity Belongs to the RNase HII family. RnhC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51975; RNASE_H_2; 1; trigger=PRU01319;
Pfam PF01351; RNase_HII; 1;
NCBIfam TIGR00716; RnhC; 1;

Features [?]

From: RNH3_BACSU (P94541)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     100     100       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  
BINDING     101     101       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     E  
BINDING     205     205       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  

Additional information [?]

Size range 257-316 amino acids
Related rules None
Fusion None