HAMAP rule MF_00053
General rule information
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| Accession | MF_00053 |
| Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 29) |
| Name | RNase_HIII |
| Scope | Bacteria |
| Template | P94541 (RNH3_BACSU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. |
| Catalytic activity | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
| Cofactor | Mn(2+) Mg(2+) Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the RNase HII family. RnhC subfamily. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| PROSITE | PS51975; RNASE_H_2; 1; trigger=PRU01319; |
| Pfam | PF01351; RNase_HII; 1; |
| NCBIfam | TIGR00716; RnhC; 1; |
Features
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| From: RNH3_BACSU (P94541) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 100 | 100 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
| BINDING | 101 | 101 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | E | ||||||||
| BINDING | 205 | 205 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
Additional information
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| Size range | 257-316 amino acids |
| Related rules | None |
| Fusion | None |