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HAMAP rule MF_00053

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General rule information [?]

Accession MF_00053
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 29)
Name RNase_HIII
Scope(s) Bacteria
Template(s) P94541 (RNH3_BACSU); [ Recover all ]
Triggered by HAMAP; MF_00053 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RNH3
Protein name RecName: Full=Ribonuclease HIII;
                 Short=RNase HIII;
Gene name Name=rnhC;

Comments [?]

FUNCTIONEndonuclease that specifically degrades the RNA of RNA-DNA hybrids.
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.;
SIMILARITYBelongs to the RNase HII family. RnhC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0004523; Molecular function:RNA-DNA hybrid ribonuclease activity
GO:0006401; Biological process:RNA catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS51975; RNASE_H_2; 1;
Pfam PF01351; RNase_HII; 1;
NCBIfam TIGR00716; RnhC; 1;

Features [?]

From: RNH3_BACSU (P94541)
Key From To Description Tag Condition FTGroup
BINDING 100 100 /ligand="a divalent metal cation"
BINDING 101 101 /ligand="a divalent metal cation"
BINDING 205 205 /ligand="a divalent metal cation"

Additional information [?]

Size range 257-316 amino acids
Related rules None
Fusion Nter: None Cter: None

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