HAMAP rule MF_00056

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00056
Accession	MF_00056
Dates	28-FEB-2005 (Created) 15-APR-2025 (Last updated, Version 24)
Name	KDO8P_synth
Scope(s)	Bacteria
Template(s)	P0A715; O66496; [ Recover all ]
Triggered by	HAMAP; MF_00056 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	KDSA
Protein name	RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase; EC=2.5.1.55; AltName: Full=3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; AltName: Full=KDO-8-phosphate synthase; Short=KDO 8-P synthase; Short=KDOPS; AltName: Full=Phospho-2-dehydro-3-deoxyoctonate aldolase;
Gene name	Name=kdsA;

Comments [?]

CATALYTIC ACTIVITY	Reaction=D-arabinose 5-phosphate + phosphoenolpyruvate + H2O = 3-deoxy- alpha-D-manno-2-octulosonate-8-phosphate + phosphate; Xref=Rhea:RHEA:14053, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57693, ChEBI:CHEBI:58702, ChEBI:CHEBI:85985; EC=2.5.1.55;
PATHWAY	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.
case defined <Property:Membrane> and <Property:Membrane=2>
PATHWAY	Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
end case
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class-I DAHP synthase family. KdsA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008676; Molecular function:3-deoxy-8-phosphooctulonate synthase activity

GO:0009103; Biological process:lipopolysaccharide biosynthetic process

GO:0019294; Biological process:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]