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HAMAP rule MF_00057

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General rule information [?]

Accession MF_00057
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name KdsB
Scope
Bacteria
Templates P04951 (KDSB_ECOLI); P42216 (KPSU5_ECOLX); Q8EEA9 (KDSB_SHEON): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KDSB
case <OC:Shewanella>
Protein name
RecName: Full=8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase;
EC 2.7.7.90;
AltName: Full=CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase;
else
Protein name
RecName: Full=3-deoxy-manno-octulosonate cytidylyltransferase;
EC 2.7.7.38;
AltName: Full=CMP-2-keto-3-deoxyoctulosonic acid synthase;
Short=CKS;
Short=CMP-KDO synthase;
end case
Gene name
kdsB

Comments [?]

case <OC:Shewanella>
Function Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
Catalytic activity RHEA:49284: 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate
EC 2.7.7.90
else
Function Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Catalytic activity RHEA:23448: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate
EC 2.7.7.38
Pathway Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.
end case
case defined <Property:Membrane> and <Property:Membrane=2>
Pathway Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the KdsB family.

Keywords [?]

Cytoplasm
Lipopolysaccharide biosynthesis
Transferase
Nucleotidyltransferase

Gene Ontology [?]

case <OC:Shewanella>
GO:0016779; Molecular function: nucleotidyltransferase activity.
else
GO:0008690; Molecular function: 3-deoxy-manno-octulosonate cytidylyltransferase activity.
GO:0033468; Biological process: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process.
end case
GO:0009103; Biological process: lipopolysaccharide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

NCBIfam TIGR00466; KdsB; 1;

Additional information [?]

Size range 230-310 amino acids
Related rules None
Fusion None
Comments kpsU from E.coli (KPSU5_ECOLX) is not a duplicate, but a kdsB from a non-K12 strain. Kdo8N is found in lipopolysaccharides of members of the Shewanella genus. (PubMed:23413030)


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