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Annotation rule MF_00057 |
General rule information
[?]
Accession |
MF_00057 |
Dates |
1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 32) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Shewanella>
Protein name |
RecName:
|
Full=8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase;
|
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EC 2.7.7.90;
|
AltName:
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Full=CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase;
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|
else
Protein name |
RecName:
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Full=3-deoxy-manno-octulosonate cytidylyltransferase;
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EC 2.7.7.38;
|
AltName:
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Full=CMP-2-keto-3-deoxyoctulosonic acid synthase;
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Short=CKS;
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Short=CMP-KDO synthase;
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|
end case
case <OC:Shewanella>
Function |
Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus. |
Catalytic activity |
RHEA:49284: 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate
EC 2.7.7.90
|
else
Function |
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. |
Catalytic activity |
RHEA:23448: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate
EC 2.7.7.38
|
Pathway |
Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. |
end case
case defined <Property:Membrane> and <Property:Membrane=2>
Pathway |
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the KdsB family. |
case <OC:Shewanella>
GO:0016779; Molecular function: nucleotidyltransferase activity.
else
GO:0008690; Molecular function: 3-deoxy-manno-octulosonate cytidylyltransferase activity.
GO:0033468; Biological process: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process.
end case
GO:0009103; Biological process: lipopolysaccharide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Additional information
[?]
Size range |
230-310 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
kpsU from E.coli (KPSU5_ECOLX) is not a duplicate, but a kdsB from a non-K12 strain. Kdo8N is found in lipopolysaccharides of members of the Shewanella genus. (PubMed:23413030) |