HAMAP rule MF_00057
General rule information
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Accession | MF_00057 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 33) |
Name | KdsB |
Scope | Bacteria |
Templates | P04951 (KDSB_ECOLI); P42216 (KPSU5_ECOLX); Q8EEA9 (KDSB_SHEON): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Shewanella>
Protein name |
|
else
Protein name |
|
end case
Gene name |
|
Comments
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case <OC:Shewanella>
Function | Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus. |
Catalytic activity | RHEA:49284: 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate
EC 2.7.7.90 |
else
Function | Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. |
Catalytic activity | RHEA:23448: 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate
EC 2.7.7.38 |
Pathway | Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. |
end case
case defined <Property:Membrane> and <Property:Membrane=2>
Pathway | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the KdsB family. |
Keywords
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Gene Ontology
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case <OC:Shewanella>
GO:0016779; Molecular function: nucleotidyltransferase activity.
else
GO:0008690; Molecular function: 3-deoxy-manno-octulosonate cytidylyltransferase activity.
GO:0033468; Biological process: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process.
GO:0033468; Biological process: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process.
end case
GO:0009103; Biological process: lipopolysaccharide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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NCBIfam | TIGR00466; KdsB; 1; |
Additional information
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Size range | 230-310 amino acids |
Related rules | None |
Fusion | None |
Comments | kpsU from E.coli (KPSU5_ECOLX) is not a duplicate, but a kdsB from a non-K12 strain. Kdo8N is found in lipopolysaccharides of members of the Shewanella genus. (PubMed:23413030) |