HAMAP rule MF_00058
General rule information
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Accession | MF_00058 |
Dates | 1-JUN-2001 (Created)
30-APR-2024 (Last updated, Version 24) |
Name | MTD |
Scope(s) |
Archaea |
Template(s) | P94951 (MTD_METKA); O29544 (MTD_ARCFU); [ Recover all ] |
Triggered by |
HAMAP; MF_00058 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MTD |
Protein name | RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase; Short=MTD; EC=1.5.98.1; AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase; |
Gene name | Name=mtd; |
Comments
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case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
FUNCTION | Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. |
else | |
FUNCTION | Catalyzes the oxidation of methylene-H(4)MPT to methenyl- H(4)MPT(+). |
end case | |
CATALYTIC ACTIVITY | Reaction=5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8- tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n); Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1; |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
PATHWAY | One-carbon metabolism; methanogenesis from CO(2); 5,10- methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8- tetrahydromethanopterin (coenzyme F420 route): step 1/1. |
end case | |
case <OC:Archaeoglobales> | |
PATHWAY | Metabolic intermediate metabolism; lactate oxidation. |
end case | |
SIMILARITY | Belongs to the MTD family. |
Keywords
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case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
Methanogenesis | |
end case | |
One-carbon metabolism | |
Oxidoreductase |
Gene Ontology
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GO:0030268; Molecular function:methylenetetrahydromethanopterin dehydrogenase activity | |
GO:0006730; Biological process:one-carbon metabolic process | |
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
GO:0019386; Biological process:methanogenesis, from carbon dioxide | |
end case | |
case <OCellular component:Archaeoglobales> | |
GO:0019516; Biological process:lactate oxidation | |
end case |
Cross-references
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Pfam | PF01993; MTD; 1; |
Features
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Additional information
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Size range | 273-283 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |