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Annotation rule MF_00058
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General rule information [?]

Accession MF_00058
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 21)
Name MTD
Scope
Archaea
Templates P94951 (MTD_METKA); O29544 (MTD_ARCFU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTD
Protein name
RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase;
Short=MTD;
EC 1.5.98.1;
AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase;
Gene name
mtd

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
else
Function Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+).
end case
Catalytic activity RHEA:16721: 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)
EC 1.5.98.1
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway One-carbon metabolism; methanogenesis from CO(2); 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1.
end case
case <OC:Archaeoglobales>
Pathway Metabolic intermediate metabolism; lactate oxidation.
end case
Similarity Belongs to the MTD family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Methanogenesis
end case
One-carbon metabolism
Oxidoreductase

Gene Ontology [?]

GO:0030268; Molecular function: methylenetetrahydromethanopterin dehydrogenase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process: methanogenesis.
end case

Cross-references [?]

Pfam PF01993; MTD; 1;

Additional information [?]

Size range 273-283 amino acids
Related rules None
Fusion None


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