HAMAP rule MF_00058
General rule information
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| Accession | MF_00058 |
| Dates | 1-JUN-2001 (Created)
4-SEP-2024 (Last updated, Version 26) |
| Name | MTD |
| Scope(s) |
Archaea |
| Template(s) | P94951 (MTD_METKA); O29544 (MTD_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00058 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MTD |
| Protein name | RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase; Short=MTD; EC=1.5.98.1; AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase; |
| Gene name | Name=mtd; |
Comments
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| FUNCTION | Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. |
| else | |
| FUNCTION | Catalyzes the oxidation of methylene-H(4)MPT to methenyl- H(4)MPT(+). |
| end case | |
| CATALYTIC ACTIVITY | Reaction=5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 H(+) = 5,10-methenyl-5,6,7,8- tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n); Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| PATHWAY | One-carbon metabolism; methanogenesis from CO(2); 5,10- methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8- tetrahydromethanopterin (coenzyme F420 route): step 1/1. |
| end case | |
| case <OC:Archaeoglobales> | |
| PATHWAY | Metabolic intermediate metabolism; lactate oxidation. |
| end case | |
| SIMILARITY | Belongs to the MTD family. |
Keywords
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| Methanogenesis | |
| end case | |
| One-carbon metabolism | |
| Oxidoreductase | |
Gene Ontology
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| GO:0030268; Molecular function:methylenetetrahydromethanopterin dehydrogenase activity | |
| GO:0006730; Biological process:one-carbon metabolic process | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| GO:0019386; Biological process:methanogenesis, from carbon dioxide | |
| end case | |
| case <OCellular component:Archaeoglobales> | |
| GO:0006089; Biological process:lactate metabolic process | |
| end case | |
Cross-references
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| Pfam | PF01993; MTD; 1; |
Features
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Additional information
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| Size range | 273-283 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |