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HAMAP rule MF_00058

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General rule information [?]

Accession MF_00058
Dates 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 23)
Name MTD
Scope(s) Archaea
Template(s) P94951 (MTD_METKA); O29544 (MTD_ARCFU); [ Recover all ]
Triggered by HAMAP; MF_00058 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTD
Protein name RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase;
                 Short=MTD;
                 EC=1.5.98.1;
AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase;
Gene name Name=mtd;

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
FUNCTIONCatalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
else
FUNCTIONCatalyzes the oxidation of methylene-H(4)MPT to methenyl- H(4)MPT(+).
end case
CATALYTIC ACTIVITY Reaction=5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8- tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n); Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYOne-carbon metabolism; methanogenesis from CO(2); 5,10- methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8- tetrahydromethanopterin (coenzyme F420 route): step 1/1.
end case
case <OC:Archaeoglobales>
PATHWAYMetabolic intermediate metabolism; lactate oxidation.
end case
SIMILARITYBelongs to the MTD family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Methanogenesis
end case
One-carbon metabolism
Oxidoreductase

Gene Ontology [?]

GO:0030268; Molecular function:methylenetetrahydromethanopterin dehydrogenase activity
GO:0006730; Biological process:one-carbon metabolic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0019386; Biological process:methanogenesis, from carbon dioxide
end case

Cross-references [?]

Pfam PF01993; MTD; 1;

Features [?]


Additional information [?]

Size range 273-283 amino acids
Related rules None
Fusion Nter: None Cter: None



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