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Annotation rule MF_00061 |
General rule information
[?]
Accession |
MF_00061 |
Dates |
1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 33) |
Propagated annotation
[?]
Identifier, protein and gene names
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case <OC:Staphylococcus> or <OC:Streptococcus>
Protein name |
RecName:
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Full=Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
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Short=CMK;
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EC 2.7.1.148;
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AltName:
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Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase;
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else
Protein name |
RecName:
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Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
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Short=CMK;
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EC 2.7.1.148;
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AltName:
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Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase;
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end case
Function |
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. |
Catalytic activity |
RHEA:18437: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)
EC 2.7.1.148
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case not <OC:Staphylococcus> and not <OC:Streptococcus>
Pathway |
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. |
end case
case <OC:Enterobacterales>
end case
Similarity |
Belongs to the GHMP kinase family. IspE subfamily. |
case not <OC:Staphylococcus> and not <OC:Streptococcus>
end case
GO:0050515; Molecular function: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity.
GO:0005524; Molecular function: ATP binding.
case not <OC:Staphylococcus> and not <OC:Streptococcus>
GO:0016114; Biological process: terpenoid biosynthetic process.
end case
From: ISPE_ECOL6 (Q8FI04) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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99
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109
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ATP
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[PL]-x-x-[GSA]-G-[LIMFV]-[GA]-[GS]-[GAD]-S-[STAG]
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ACT_SITE
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10
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10
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K
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ACT_SITE
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141
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141
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D
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Additional information
[?]
Size range |
255-329 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
In CHLPN there is a remnant of an ispE gene but which is interrupted by a probable natural frameshift (all CHLPN strains have it). It is orf CP0905 |