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HAMAP rule MF_00062

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General rule information [?]

Accession MF_00062
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 31)
Name Sulf_adenylyltr_sub1
Template P23845 (CYSN_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Sulfate adenylyltransferase subunit 1;
AltName: Full=ATP-sulfurylase large subunit;
AltName: Full=Sulfate adenylate transferase;
Gene name

Comments [?]

Function With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Catalytic activity RHEA:18133: ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate
Pathway Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Subunit Heterodimer composed of CysD, the smaller subunit, and CysN.
Similarity Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0004781; Molecular function: sulfate adenylyltransferase (ATP) activity.
GO:0000103; Biological process: sulfate assimilation.

Cross-references [?]

Pfam PF00009; GTP_EFTU; 1;
PROSITE PS00301; G_TR_1; 1;
PS51722; G_TR_2; 1;

Features [?]

From: CYSN_ECOLI (P23845)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     34     41       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     G-x(4)-G-K-S  
BINDING     113     117       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-[ATC]-P-G-H  
BINDING     168     171       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-[IM]-D  

Additional information [?]

Size range 441-494 amino acids
Related rules None
Fusion Nter: None; Cter: MF_00065 (cysC)
Comments Problematic entry. N-terminal too short in MYCTU. If in a nodulating bacteria, has to be done manually because of the presence of both cysN and nodQ.