HAMAP rule MF_00065
General rule information
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| Accession | MF_00065 |
| Dates | 1-JUN-2001 (Created)
14-MAY-2024 (Last updated, Version 37) |
| Name | Adenylyl_sulf_kinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A6J1 (CYSC_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00065 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CYSC |
| Protein name | RecName: Full=Adenylyl-sulfate kinase; EC=2.7.1.25; AltName: Full=APS kinase; AltName: Full=ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; AltName: Full=Adenosine-5'-phosphosulfate kinase; |
| Gene name | Name=cysC; |
Comments
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| FUNCTION | Catalyzes the synthesis of activated sulfate. |
| CATALYTIC ACTIVITY | Reaction=adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+); Xref=Rhea:RHEA:24152, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58243, ChEBI:CHEBI:58339, ChEBI:CHEBI:456216; EC=2.7.1.25; |
| PATHWAY | Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. |
| SIMILARITY | Belongs to the APS kinase family. |
Keywords
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Gene Ontology
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| GO:0004020; Molecular function:adenylylsulfate kinase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0000103; Biological process:sulfate assimilation |
| GO:0070814; Biological process:hydrogen sulfide biosynthetic process |
Cross-references
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Features
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| From: CYSC_ECOLI (P0A6J1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 35 | 42 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x(4)-G-K-[ST] | ||||||||
| ACT_SITE | 109 | 109 | /note="Phosphoserine intermediate" | S | ||||||||
Additional information
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| Size range | 155-214 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_00062 (cysN); MF_00066 (sat) Cter: None |
| Comments | Problematic entry |