HAMAP rule MF_00068
General rule information
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Accession | MF_00068 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 37) |
Name | MurQ |
Scope | Bacteria |
Template | P76535 (MURQ_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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case <OC:Pseudomonadota>
Function | Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. |
else
Function | Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. |
end case
Catalytic activity | RHEA:26410: H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate
EC 4.2.1.126 |
Pathway | Amino-sugar metabolism; N-acetylmuramate degradation. |
case <OC:Pseudomonadota>
Pathway | Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. |
Cell wall biogenesis; peptidoglycan recycling. |
end case
Subunit | Homodimer. |
case <OC:Enterobacterales>
Induction | Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate. |
end case
Miscellaneous | A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product. |
Similarity | Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. |
Keywords
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Gene Ontology
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GO:0016835; Molecular function: carbon-oxygen lyase activity.
GO:0006040; Biological process: amino sugar metabolic process.
GO:0006040; Biological process: amino sugar metabolic process.
case <OC:Pseudomonadota>
GO:0009254; Biological process: peptidoglycan turnover.
end case
Cross-references
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PROSITE | PS01272; GCKR; 1; |
PS51464; SIS; 1; trigger=PRU00797; | |
Pfam | PF01380; SIS; 1; |
NCBIfam | TIGR00274; TIGR00274; 1; |
Features
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From: MURQ_ECOLI (P76535) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 83 | 83 | Proton donor | E | ||||||||
ACT_SITE | 114 | 114 | E |
Additional information
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Size range | 274-316 amino acids |
Related rules | None |
Fusion | None |