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HAMAP rule MF_00068

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General rule information [?]

Accession MF_00068
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 37)
Name MurQ
Scope
Bacteria
Template P76535 (MURQ_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MURQ
Protein name
RecName: Full=N-acetylmuramic acid 6-phosphate etherase;
Short=MurNAc-6-P etherase;
EC 4.2.1.126;
AltName: Full=N-acetylmuramic acid 6-phosphate hydrolase;
AltName: Full=N-acetylmuramic acid 6-phosphate lyase;
Gene name
murQ

Comments [?]

case <OC:Pseudomonadota>
Function Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
else
Function Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
end case
Catalytic activity RHEA:26410: H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate
EC 4.2.1.126
Pathway Amino-sugar metabolism; N-acetylmuramate degradation.
case <OC:Pseudomonadota>
Pathway Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.
Cell wall biogenesis; peptidoglycan recycling.
end case
Subunit Homodimer.
case <OC:Enterobacterales>
Induction Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate.
end case
Miscellaneous A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
Similarity Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.

Keywords [?]

Carbohydrate metabolism
Lyase

Gene Ontology [?]

GO:0016835; Molecular function: carbon-oxygen lyase activity.
GO:0006040; Biological process: amino sugar metabolic process.
case <OC:Pseudomonadota>
GO:0009254; Biological process: peptidoglycan turnover.
end case

Cross-references [?]

PROSITE PS01272; GCKR; 1;
PS51464; SIS; 1; trigger=PRU00797;
Pfam PF01380; SIS; 1;
NCBIfam TIGR00274; TIGR00274; 1;

Features [?]

From: MURQ_ECOLI (P76535)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     83     83       Proton donor     E  
ACT_SITE     114     114             E  

Additional information [?]

Size range 274-316 amino acids
Related rules None
Fusion None


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