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Annotation rule MF_00068 |
General rule information
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Accession |
MF_00068 |
Dates |
1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 35) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=N-acetylmuramic acid 6-phosphate etherase;
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Short=MurNAc-6-P etherase;
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EC 4.2.1.126;
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AltName:
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Full=N-acetylmuramic acid 6-phosphate hydrolase;
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AltName:
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Full=N-acetylmuramic acid 6-phosphate lyase;
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case <OC:Proteobacteria>
Function |
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. |
else
Function |
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. |
end case
Catalytic activity |
RHEA:26410: H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate
EC 4.2.1.126
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Pathway |
Amino-sugar metabolism; N-acetylmuramate degradation. |
case <OC:Proteobacteria>
Pathway |
Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. |
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Cell wall biogenesis; peptidoglycan recycling. |
end case
case <OC:Enterobacterales>
Induction |
Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate. |
end case
Miscellaneous |
A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product. |
Similarity |
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. |
GO:0016835; Molecular function: carbon-oxygen lyase activity.
GO:0006040; Biological process: amino sugar metabolic process.
case <OC:Proteobacteria>
GO:0009254; Biological process: peptidoglycan turnover.
end case
From: MURQ_ECOLI (P76535) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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83
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83
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Proton donor
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E
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ACT_SITE
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114
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114
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E
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Additional information
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Size range |
274-316 amino acids |
Related rules |
None |
Fusion |
None |