HAMAP rule MF_00072

General rule information [?]

Accession	MF_00072
Dates	1-JUN-2001 (Created) 28-NOV-2023 (Last updated, Version 35)
Name	Rel_fac_3
Scope(s)	Bacteria
Template(s)	P0A7I4 (RF3_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00072 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RF3
Protein name	RecName: Full=Peptide chain release factor 3; Short=RF-3;
Gene name	Name=prfC;

Comments [?]

FUNCTION	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005525; Molecular function:GTP binding

GO:0016149; Molecular function:translation release factor activity, codon specific

GO:0006449; Biological process:regulation of translational termination

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: RF3_ECOLI (P0A7I4)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

S-H-P-D-A-G-K-T

BINDING

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

D-T-P-G-H

BINDING

142

145

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

N-K-[LMYCVF]-D

Additional information [?]