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Annotation rule MF_00072
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General rule information [?]

Accession MF_00072
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 31)
Name Rel_fac_3
Scope
Bacteria
Template P0A7I4 (RF3_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RF3
Protein name
RecName: Full=Peptide chain release factor 3;
Short=RF-3;
Gene name
prfC

Comments [?]

Function Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
Subcellular location Cytoplasm.
Similarity Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0016149; Molecular function: translation release factor activity, codon specific.
GO:0006449; Biological process: regulation of translational termination.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
TIGRFAMs TIGR00503; PrfC; 1;
PROSITE PS00301; G_TR_1; 1;
PS51722; G_TR_2; 1;

Features [?]

From: RF3_ECOLI (P0A7I4)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     20     27       GTP     S-H-P-D-A-G-K-T  
NP_BIND     88     92       GTP     D-T-P-G-H  
NP_BIND     142     145       GTP     N-K-[LMYCVF]-D  

Additional information [?]

Size range 510-556 amino acids
Related rules None
Fusion None