HAMAP logo

HAMAP rule MF_00072

Send feedback

General rule information [?]

Accession MF_00072
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 35)
Name Rel_fac_3
Scope(s) Bacteria
Template(s) P0A7I4 (RF3_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00072 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RF3
Protein name RecName: Full=Peptide chain release factor 3;
Gene name Name=prfC;

Comments [?]

FUNCTIONIncreases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
SIMILARITYBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005525; Molecular function:GTP binding
GO:0016149; Molecular function:translation release factor activity, codon specific
GO:0006449; Biological process:regulation of translational termination
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00009; GTP_EFTU; 1;
Pfam PF03144; GTP_EFTU_D2; 1;
NCBIfam TIGR00503; PrfC; 1;
PROSITE PS00301; G_TR_1; 1;
PROSITE PS51722; G_TR_2; 1;

Features [?]

From: RF3_ECOLI (P0A7I4)
Key From To Description Tag Condition FTGroup
BINDING 20 27 /ligand="GTP"
BINDING 88 92 /ligand="GTP"
BINDING 142 145 /ligand="GTP"

Additional information [?]

Size range 510-556 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)