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HAMAP rule MF_00075

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General rule information [?]

Accession MF_00075
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 44)
Name IF_1
Scope(s) Bacteria
Template(s) P69222 (IF1_ECOLI); Q5SHR1 (IF1_THET8); [ Recover all ]
Triggered by HAMAP; MF_00075 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OG:Chloroplast>
Identifier IF1
Protein name RecName: Full=Translation initiation factor IF-1;
end case
case <OG:Chloroplast>
Identifier IF1C
Protein name RecName: Full=Translation initiation factor IF-1, chloroplastic;
end case
Gene name Name=infA;

Comments [?]

FUNCTIONOne of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
SUBUNITComponent of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
case not <OG:Chloroplast>
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the IF-1 family.

Keywords [?]

case not <OG:Chloroplast>
end case
Initiation factor
Protein biosynthesis
case <OC:Bacillaceae> and <FT:1>
end case

Gene Ontology [?]

GO:0019843; Molecular function:rRNA binding
GO:0003743; Molecular function:translation initiation factor activity
GO:0006413; Biological process:translational initiation
GO:0043022; Molecular function:ribosome binding
case not <OG:Chloroplast>
GO:0005737; Cellular component:cytoplasm
end case
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF01176; eIF-1a; 1;
NCBIfam TIGR00008; InfA; 1;
PROSITE PS50832; S1_IF1_TYPE; 1;

Features [?]

From: IF1_BACSU (P20458)
Key From To Description Tag Condition FTGroup
case <OC:Bacillaceae>
MOD_RES 60 60 /note="Phosphotyrosine" Y
end case

Additional information [?]

Size range 70-113 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in MYCSP Pseudogene in the plastid genome in most rosids (including ARATH), and Solanaceae (including TOBAC). MEDLINE=21149877; PubMed=11251102; DOI=10.1105/tpc.13.3.645; Millen R.S., Olmstead R.G., Adams K.L., Palmer J.D., Lao N.T., Heggie L., Kavanagh T.A., Hibberd J.M., Gray J.C., Morden C.W., Calie P.J., Jermiin L.S., Wolfe K.H.; "Many parallel losses of infA from chloroplast DNA during angiosperm evolution with multiple independent transfers to the nucleus."; Plant Cell 13:645-658(2001).

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