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Annotation rule MF_00075
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General rule information [?]

Accession MF_00075
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 43)
Name IF_1
Templates P69222 (IF1_ECOLI); Q5SHR1 (IF1_THET8): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OG:Chloroplast>
Protein name
RecName: Full=Translation initiation factor IF-1;
end case
case <OG:Chloroplast>
Protein name
RecName: Full=Translation initiation factor IF-1, chloroplastic;
end case
Gene name

Comments [?]

Function One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Subunit Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
case not <OG:Chloroplast>
Subcellular location Cytoplasm.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the IF-1 family.

Keywords [?]

case not <OG:Chloroplast>
end case
case <OC:Bacillaceae> and <FT:1>
end case

Gene Ontology [?]

GO:0019843; Molecular function: rRNA binding.
GO:0003743; Molecular function: translation initiation factor activity.
GO:0006413; Biological process: translational initiation.
GO:0043022; Molecular function: ribosome binding.
case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF01176; eIF-1a; 1;
TIGRFAMs TIGR00008; InfA; 1;
PROSITE PS50832; S1_IF1_TYPE; 1; trigger=PRU00181;

Features [?]

case <OC:Bacillaceae>
From: IF1_BACSU (P20458)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     60     60       Phosphotyrosine     Y  
end case

Additional information [?]

Size range 70-113 amino acids
Related rules None
Fusion None
Comments Possible wrong start in MYCSP Pseudogene in the plastid genome in most rosids (including ARATH), and Solanaceae (including TOBAC). MEDLINE=21149877; PubMed=11251102; DOI=10.1105/tpc.13.3.645; Millen R.S., Olmstead R.G., Adams K.L., Palmer J.D., Lao N.T., Heggie L., Kavanagh T.A., Hibberd J.M., Gray J.C., Morden C.W., Calie P.J., Jermiin L.S., Wolfe K.H.; "Many parallel losses of infA from chloroplast DNA during angiosperm evolution with multiple independent transfers to the nucleus."; Plant Cell 13:645-658(2001).