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HAMAP rule MF_00077

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General rule information [?]

Accession MF_00077
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name tRNA_methyltr_aTrm56
Scope(s) Archaea
Template(s) O58214 (TRM56_PYRHO); Q9UYD1 (TRM56_PYRAB); O29507 (TRM56_ARCFU); [ Recover all ]
Triggered by HAMAP; MF_00077 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRM56
Protein name RecName: Full=tRNA (cytidine(56)-2'-O)-methyltransferase;
                 EC=2.1.1.206;
AltName: Full=tRNA ribose 2'-O-methyltransferase aTrm56;

Comments [?]

FUNCTIONSpecifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
CATALYTIC ACTIVITY Reaction=cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O- methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42968, Rhea:RHEA-COMP:10308, Rhea:RHEA-COMP:10309, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.206;
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the aTrm56 family.

Keywords [?]


Gene Ontology [?]

GO:0008175; Molecular function:tRNA methyltransferase activity
GO:0002128; Biological process:tRNA nucleoside ribose methylation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01994; Trm56; 1;
Pfam PF01966; HD; 0-1;
NCBIfam TIGR00277; HDIG; 0-1;
PROSITE PS51831; HD; 0-1;

Features [?]

From: TRM56_PYRHO (O58214)
Key From To Description Tag Condition FTGroup
BINDING 109 113 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
G-[GAS]-[ED]-[KR]-V
BINDING 127 134 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[VI]-[GAS]-N-Q-P-H-S-E
BINDING 80 80 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
L

Additional information [?]

Size range 168-218 amino acids
Related rules None
Fusion Nter: None Cter: <HD domain>
Comments Shorter N-terminus in SULAC and SACS2.



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