HAMAP rule MF_00078

General rule information [?]

Accession	MF_00078
Dates	1-JUN-2001 (Created) 22-MAY-2024 (Last updated, Version 20)
Name	PMDh_S
Scope(s)	Archaea
Template(s)	Q9YA49 (Y2089_AERPE); Q8PWQ2 (Y1524_METMA); Q5JGJ7 (Y1248_THEKO); [ Recover all ]
Triggered by	HAMAP; MF_00078 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PMDHS
Protein name	RecName: Full=Phosphomevalonate dehydratase small subunit; Short=PMDh small subunit; Short=PMDh-S; EC=4.2.1.182;

Comments [?]

FUNCTION	Component of a hydro-lyase that catalyzes the dehydration of mevalonate 5-phosphate (MVA5P) to form trans-anhydromevalonate 5- phosphate (tAHMP). Involved in the archaeal mevalonate (MVA) pathway, which provides fundamental precursors for isoprenoid biosynthesis, such as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
CATALYTIC ACTIVITY	Reaction=(R)-5-phosphomevalonate = (2E)-3-methyl-5-phosphooxypent-2- enoate + H2O; Xref=Rhea:RHEA:78975, ChEBI:CHEBI:15377, ChEBI:CHEBI:58146, ChEBI:CHEBI:229665; EC=4.2.1.182; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:78976;
PATHWAY	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway.
SUBUNIT	Heterodimer composed of a large subunit (PMDh-L) and a small subunit (PMDh-S).
SIMILARITY	Belongs to the AcnX type II small subunit family.

Keywords [?]

Gene Ontology [?]

GO:0016836; Molecular function:hydro-lyase activity

GO:0019287; Biological process:isopentenyl diphosphate biosynthetic process, mevalonate pathway

Cross-references [?]

Pfam	PF01989; AcnX_swivel_put; 1;
PIRSF	PIRSF004966; UCP004966; 1;

Features [?]

From: PMDHS_AERPE (Q9YA49)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

/note="Proton acceptor"

Additional information [?]