 |
|
| Annotation rule MF_00079 |
General rule information
[?]
| Accession | MF_00079 |
| Dates | 1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 42) |
| Name | HisG_Long |
| Scope | Bacteria
Archaea |
| Templates | P60757 (HIS1_ECOLI); P00499 (HIS1_SALTY); P9WMN1 (HIS1_MYCTU): [Recover all] |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||||||||||||||
| Gene name |
|
Comments
[?]
| Function | Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. |
| Catalytic activity | RHEA:18473: 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
EC 2.4.2.17 |
| Cofactor | Mg(2+) |
| Activity regulation | Feedback inhibited by histidine. |
| Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. |
case <OC:Enterobacterales> or <OC:Mycobacteriaceae>
| Subunit | Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme. |
end case
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the ATP phosphoribosyltransferase family. Long subfamily. |
Keywords
[?]
Amino-acid biosynthesis
ATP-binding
Cytoplasm
Glycosyltransferase
Histidine biosynthesis
Magnesium
Metal-binding
Nucleotide-binding
Transferase
ATP-binding
Cytoplasm
Glycosyltransferase
Histidine biosynthesis
Magnesium
Metal-binding
Nucleotide-binding
Transferase
Gene Ontology
[?]
GO:0003879; Molecular function: ATP phosphoribosyltransferase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0000287; Molecular function: magnesium ion binding.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
[?]
| Pfam | PF01634; HisG; 1; |
| TIGRFAMs | TIGR00070; HisG; 1; |
| TIGR03455; HisG_C-term; 1; | |
| PROSITE | PS01316; ATP_P_PHORIBOSYLTR; 1; |
Additional information
[?]
| Size range | 281-325 amino acids |
| Related rules | MF_01018 (HIS1) |
| Fusion | None |
| Comments | Possible wrong start in HAEIN. Possible wrong start in ARCFU; not shown in alignment and not taken into account in size range. See MF_01018 for the entry relevant to the "short" hisG. |