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Annotation rule MF_00079
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General rule information [?]

Accession MF_00079
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 42)
Name HisG_Long
Scope
Bacteria
Archaea
Templates P60757 (HIS1_ECOLI); P00499 (HIS1_SALTY); P9WMN1 (HIS1_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HIS1
Protein name
RecName: Full=ATP phosphoribosyltransferase;
Short=ATP-PRT;
Short=ATP-PRTase;
EC 2.4.2.17;
Gene name
hisG

Comments [?]

Function Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity RHEA:18473: 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
EC 2.4.2.17
Cofactor Mg(2+)
Activity regulation Feedback inhibited by histidine.
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Enterobacterales> or <OC:Mycobacteriaceae>
Subunit Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003879; Molecular function: ATP phosphoribosyltransferase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01634; HisG; 1;
TIGRFAMs TIGR00070; HisG; 1;
TIGR03455; HisG_C-term; 1;
PROSITE PS01316; ATP_P_PHORIBOSYLTR; 1;

Additional information [?]

Size range 281-325 amino acids
Related rules MF_01018 (HIS1)
Fusion None
Comments Possible wrong start in HAEIN. Possible wrong start in ARCFU; not shown in alignment and not taken into account in size range. See MF_01018 for the entry relevant to the "short" hisG.