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HAMAP rule MF_00079

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General rule information [?]

Accession MF_00079
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43)
Name HisG_Long
Scope(s) Bacteria
Template(s) P60757 (HIS1_ECOLI); P00499 (HIS1_SALTY); P9WMN1 (HIS1_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_00079 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS1
Protein name RecName: Full=ATP phosphoribosyltransferase;
Gene name Name=hisG;

Comments [?]

FUNCTIONCatalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
CATALYTIC ACTIVITY Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:73183; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
ACTIVITY REGULATIONFeedback inhibited by histidine.
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Enterobacterales> or <OC:Mycobacteriaceae>
SUBUNITEquilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.
end case
SIMILARITYBelongs to the ATP phosphoribosyltransferase family. Long subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003879; Molecular function:ATP phosphoribosyltransferase activity
GO:0000287; Molecular function:magnesium ion binding
GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01634; HisG; 1;
NCBIfam TIGR00070; HisG; 1;
NCBIfam TIGR03455; HisG_C-term; 1;

Features [?]

Additional information [?]

Size range 281-325 amino acids
Related rules MF_01018
Fusion Nter: None Cter: None
Comments Possible wrong start in HAEIN. Possible wrong start in ARCFU; not shown in alignment and not taken into account in size range. See MF_01018 for the entry relevant to the "short" hisG.

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