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HAMAP rule MF_00091

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General rule information [?]

Accession MF_00091
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 28)
Name LuxS
Scope(s) Bacteria
Template(s) O34667 (LUXS_BACSU); Q9PN97 (LUXS_CAMJE); Q9RRU8 (LUXS_DEIRA); P45578 (LUXS_ECOLI); P44007 (LUXS_HAEIN); [ Recover all ]
Triggered by HAMAP; MF_00091 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LUXS
Protein name RecName: Full=S-ribosylhomocysteine lyase;
AltName: Full=AI-2 synthesis protein;
AltName: Full=Autoinducer-2 production protein LuxS;
Gene name Name=luxS;

Comments [?]

FUNCTIONInvolved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
CATALYTIC ACTIVITY Reaction=S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5- dihydroxypentane-2,3-dione + L-homocysteine; Xref=Rhea:RHEA:17753, ChEBI:CHEBI:29484, ChEBI:CHEBI:58195, ChEBI:CHEBI:58199; EC=;
case <FTGroup:1>
COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
end case
SIMILARITYBelongs to the LuxS family.

Keywords [?]

Gene Ontology [?]

GO:0043768; Molecular function:S-ribosylhomocysteine lyase activity
GO:0009372; Biological process:quorum sensing

Cross-references [?]

Pfam PF02664; LuxS; 1;

Features [?]

From: LUXS_BACSU (O34667)
Key From To Description Tag Condition FTGroup
BINDING 54 54 /ligand="Fe cation"
H 1
BINDING 58 58 /ligand="Fe cation"
H 1
BINDING 126 126 /ligand="Fe cation"
C 1

Additional information [?]

Size range 151-173 amino acids
Related rules None
Fusion Nter: None Cter: None

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