HAMAP rule MF_00091

General rule information [?]

Accession	MF_00091
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 28)

Name

LuxS

Scope

Bacteria

Templates

O34667 (LUXS_BACSU); Q9PN97 (LUXS_CAMJE); Q9RRU8 (LUXS_DEIRA); P45578 (LUXS_ECOLI); P44007 (LUXS_HAEIN): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

LUXS

Protein name

RecName:		Full=S-ribosylhomocysteine lyase;
		EC 4.4.1.21;
AltName:		Full=AI-2 synthesis protein;
AltName:		Full=Autoinducer-2 production protein LuxS;

Gene name

luxS

Comments [?]

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Catalytic activity	RHEA:17753: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine EC 4.4.1.21

case <FTGroup:1>

Cofactor

Fe cation
Note: Binds 1 Fe cation per subunit.

end case

Subunit	Homodimer.
Similarity	Belongs to the LuxS family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

GO:0043768; Molecular function: S-ribosylhomocysteine lyase activity.
GO:0009372; Biological process: quorum sensing.

Cross-references [?]

Pfam	PF02664; LuxS; 1;
PRINTS	PR01487; LUXSPROTEIN; 1;

Features [?]

From: LUXS_BACSU (O34667)

Key From To Description Tag Condition FTGroup

BINDING 54 54 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 H 1

BINDING 58 58 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 H 1

BINDING 126 126 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 C 1

Additional information [?]