Annotation rule MF_00091
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General rule information [?]

Accession MF_00091
Dates 1-JUN-2001 (Created)
10-OCT-2014 (Last updated, Version 24)
Name LuxS
Scope Bacteria
Templates O34667 (LUXS_BACSU); Q9PN97 (LUXS_CAMJE); Q9RRU8 (LUXS_DEIRA); P45578 (LUXS_ECOLI); P44007 (LUXS_HAEIN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LUXS
Protein name
RecName: Full=S-ribosylhomocysteine lyase;
EC=4.4.1.21;
AltName: Full=AI-2 synthesis protein;
AltName: Full=Autoinducer-2 production protein LuxS;
Gene name
luxS

Comments [?]

Function Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Catalytic activity S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.
case <FTGroup:1>
Cofactor Fe cation
Note: Binds 1 Fe cation per subunit.
end case
Subunit Homodimer.
Similarity Belongs to the LuxS family.

Keywords [?]

Quorum sensing
Autoinducer synthesis
Lyase
case <FTGroup:1>
Iron
Metal-binding
end case

Gene Ontology [?]

GO:0043768; Molecular function: S-ribosylhomocysteine lyase activity.
GO:0009372; Biological process: quorum sensing.

Cross-references [?]

Pfam PF02664; LuxS; 1;
PRINTS PR01487; LUXSPROTEIN; 1;

Features [?]

From: LUXS_BACSU (O34667)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     54     54       Iron     H   1
METAL     58     58       Iron     H   1
METAL     126     126       Iron     C   1

Additional information [?]

Size range 151-173 amino acids
Related rules None
Fusion None


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