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HAMAP rule MF_00094

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General rule information [?]

Accession MF_00094
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 21)
Name Rel_fac_2
Scope(s) Bacteria
Template(s) P07012 (RF2_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00094 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RF2
Protein name RecName: Full=Peptide chain release factor 2;
Gene name Name=prfB;

Comments [?]

FUNCTIONPeptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
case <FT:1>
PTMMethylated by PrmC. Methylation increases the termination efficiency of RF2.
end case
SIMILARITYBelongs to the prokaryotic/mitochondrial release factor family.

Keywords [?]

Gene Ontology [?]

GO:0016149; Molecular function:translation release factor activity, codon specific
GO:0006415; Biological process:translational termination
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00472; RF-1; 1;
NCBIfam TIGR00020; PrfB; 1;

Features [?]

From: RF2_ECOLI (P07012)
Key From To Description Tag Condition FTGroup
MOD_RES 252 252 /note="N5-methylglutamine" Q

Additional information [?]

Size range 359-377 amino acids
Related rules MF_00093
Fusion Nter: None Cter: None
Comments In about 70% of bacterial genomes the mRNA encoding RF-2 has 2 partially overlapping reading frames. Synthesis of full-length RF-2 requires +1 frameshifting at the end of the first open reading frame, usually on a UGA codon. This frameshifting serves an autoregulatory function; when RF-2 levels are low frameshifting occurs and full-length protein is produced.

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