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Annotation rule MF_00094 |
Accession | MF_00094 |
Dates | 1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 20) |
Name | Rel_fac_2 |
Scope | Bacteria |
Template | P07012 (RF2_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. |
Subcellular location | Cytoplasm. |
Ptm | Methylated by PrmC. Methylation increases the termination efficiency of RF2. |
Similarity | Belongs to the prokaryotic/mitochondrial release factor family. |
From: RF2_ECOLI (P07012) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 252 | 252 | N5-methylglutamine | Q |
Size range | 359-377 amino acids |
Related rules | MF_00093 (RF1) |
Fusion | None |
Comments | In about 70% of bacterial genomes the mRNA encoding RF-2 has 2 partially overlapping reading frames. Synthesis of full-length RF-2 requires +1 frameshifting at the end of the first open reading frame, usually on a UGA codon. This frameshifting serves an autoregulatory function; when RF-2 levels are low frameshifting occurs and full-length protein is produced. |