HAMAP rule MF_00101
General rule information
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| Accession | MF_00101 |
| Dates | 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 39) |
| Name | AcpS |
| Scope(s) |
Bacteria |
| Template(s) | P96618 (ACPS_BACSU); P24224 (ACPS_ECOLI); P0A2W6 (ACPS_STRPN); [ Recover all ] |
| Triggered by |
HAMAP; MF_00101 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ACPS |
| Protein name | RecName: Full=Holo-[acyl-carrier-protein] synthase; Short=Holo-ACP synthase; EC=2.7.8.7; AltName: Full=4'-phosphopantetheinyl transferase AcpS; |
| Gene name | Name=acpS; |
Comments
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| FUNCTION | Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. |
| CATALYTIC ACTIVITY | Reaction=apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:12068, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:9690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:58343, ChEBI:CHEBI:64479; EC=2.7.8.7; |
| case <FT:1> or <FT:2> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the P-Pant transferase superfamily. AcpS family. |
Keywords
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| Cytoplasm | |
| Fatty acid biosynthesis | |
| Fatty acid metabolism | |
| Lipid biosynthesis | |
| Lipid metabolism | |
| case <FT:1> or <FT:2> | |
| Magnesium | |
| Metal-binding | |
| end case | |
| Transferase | |
Gene Ontology
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| GO:0008897; Molecular function:holo-[acyl-carrier-protein] synthase activity | |
| case <FT:1> or <FT:2> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0006633; Biological process:fatty acid biosynthetic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: ACPS_ECOLI (P24224) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 9 | 9 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
[DE] | ||||||||
| BINDING | 58 | 58 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
[EQ] | ||||||||
Additional information
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| Size range | 108-157 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong C-terminal sequence in THEMA; not shown in alignment and not used in size range |