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HAMAP rule MF_00101

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General rule information [?]

Accession MF_00101
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 38)
Name AcpS
Scope(s) Bacteria
Template(s) P96618 (ACPS_BACSU); P24224 (ACPS_ECOLI); P0A2W6 (ACPS_STRPN); [ Recover all ]
Triggered by HAMAP; MF_00101 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACPS
Protein name RecName: Full=Holo-[acyl-carrier-protein] synthase;
                 Short=Holo-ACP synthase;
AltName: Full=4'-phosphopantetheinyl transferase AcpS;
Gene name Name=acpS;

Comments [?]

FUNCTIONTransfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
CATALYTIC ACTIVITY Reaction=apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo- [ACP]; Xref=Rhea:RHEA:12068, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:9690, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57287, ChEBI:CHEBI:58343, ChEBI:CHEBI:64479; EC=;
case <FT:1> or <FT:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITYBelongs to the P-Pant transferase superfamily. AcpS family.

Keywords [?]

Gene Ontology [?]

GO:0008897; Molecular function:holo-[acyl-carrier-protein] synthase activity
case <FT:1> or <FT:2>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0006633; Biological process:fatty acid biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01648; ACPS; 1;
NCBIfam TIGR00516; AcpS; 1;
NCBIfam TIGR00556; Pantethn_trn; 1;

Features [?]

From: ACPS_ECOLI (P24224)
Key From To Description Tag Condition FTGroup
BINDING 9 9 /ligand="Mg(2+)"
BINDING 58 58 /ligand="Mg(2+)"

Additional information [?]

Size range 108-157 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong C-terminal sequence in THEMA; not shown in alignment and not used in size range

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