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HAMAP rule MF_00104

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General rule information [?]

Accession MF_00104
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 34)
Name RNase_III
Scope(s) Bacteria
Template(s) O67082 (RNC_AQUAE); P51833 (RNC_BACSU); P0A7Y0 (RNC_ECOLI); Q52698 (RNC_RHOCA); Q56056 (RNC_SALTY); Q9ZBQ7 (RNC_STRCO); Q9X0I6 (RNC_THEMA); [ Recover all ]
Triggered by HAMAP; MF_00104 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RNC
Protein name RecName: Full=Ribonuclease 3;
AltName: Full=Ribonuclease III;
                 Short=RNase III;
Gene name Name=rnc;

Comments [?]

FUNCTIONDigests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;

Keywords [?]

Gene Ontology [?]

GO:0004525; Molecular function:ribonuclease III activity
GO:0006397; Biological process:mRNA processing
GO:0006364; Biological process:rRNA processing
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00035; dsrm; 1;
Pfam PF00636; Ribonuclease_3; 1;
NCBIfam TIGR02191; RNaseIII; 1;
PROSITE PS00517; RNASE_3_1; 1;
PROSITE PS50142; RNASE_3_2; 1;

Features [?]

From: RNC_AQUAE (O67082)
Key From To Description Tag Condition FTGroup
ACT_SITE 44 44 D
ACT_SITE 110 110 E
BINDING 40 40 /ligand="Mg(2+)"
BINDING 107 107 /ligand="Mg(2+)"
BINDING 110 110 /ligand="Mg(2+)"

Additional information [?]

Size range 221-369 amino acids
Related rules None
Fusion Nter: <Unknown> Cter: None
Comments Often predicted too short. Some Mycoplasmas lack the DRBM domain. Mycoplasma gallisepticum strains have an unknown N-terminal extension of about 400 aa. ROSHA and TRES6 are slightly longer in the middle; ROSHA has 2 DRBM domains.

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