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Annotation rule MF_00104
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General rule information [?]

Accession MF_00104
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 31)
Name RNase_III
Templates O67082 (RNC_AQUAE); P51833 (RNC_BACSU); P0A7Y0 (RNC_ECOLI); Q52698 (RNC_RHOCA); Q56056 (RNC_SALTY); Q9ZBQ7 (RNC_STRCO); Q9X0I6 (RNC_THEMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Ribonuclease 3;
AltName: Full=Ribonuclease III;
Short=RNase III;
Gene name

Comments [?]

Function Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Catalytic activity Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
Cofactor Mg(2+)
Subunit Homodimer.
Subcellular location Cytoplasm.

Keywords [?]

case <FT:3> or <FT:4> or <FT:5>
end case
case <Feature:PS50137>
end case

Gene Ontology [?]

GO:0004525; Molecular function: ribonuclease III activity.
GO:0006397; Biological process: mRNA processing.
GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00035; dsrm; 1;
PF00636; Ribonuclease_3; 1;
TIGRFAMs TIGR02191; RNaseIII; 1;
PROSITE PS50137; DS_RBD; 1; trigger=PRU00266;
PS00517; RNASE_3_1; 1;
PS50142; RNASE_3_2; 1; trigger=PRU00177;

Features [?]

From: RNC_AQUAE (O67082)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     44     44             D  
ACT_SITE     110     110             E  
METAL     40     40       Magnesium     E  
METAL     107     107       Magnesium     [DENS]  
METAL     110     110       Magnesium     E  

Additional information [?]

Size range 221-369 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: None
Comments Often predicted too short. Some Mycoplasmas lack the DRBM domain. Mycoplasma gallisepticum strains have an unknown N-terminal extension of about 400 aa. ROSHA and TRES6 are slightly longer in the middle; ROSHA has 2 DRBM domains.