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Annotation rule MF_00108 |
General rule information
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Accession |
MF_00108 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 32) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;
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EC 2.7.7.60;
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AltName:
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Full=4-diphosphocytidyl-2C-methyl-D-erythritol synthase;
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AltName:
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Full=MEP cytidylyltransferase;
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Short=MCT;
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Function |
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). |
Catalytic activity |
RHEA:13429: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate
EC 2.7.7.60
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Pathway |
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. |
case <OC:Enterobacterales>
end case
Similarity |
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. |
GO:0050518; Molecular function: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.
From: ISPD_ECOLI (Q46893) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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SITE
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20
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20
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Transition state stabilizer
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R
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SITE
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27
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27
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Transition state stabilizer
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K
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SITE
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157
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157
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Positions MEP for the nucleophilic attack
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R
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SITE
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213
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213
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Positions MEP for the nucleophilic attack
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K
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Additional information
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Size range |
211-291 amino acids |
Related rules |
MF_01520 (ISPDF supersedes the current rule) |
Fusion |
None |
Comments |
See MF_01520 for bifunctional ispDF |