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HAMAP rule MF_00108

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General rule information [?]

Accession MF_00108
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name IspD
Scope(s) Bacteria
Template(s) Q46893 (ISPD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00108 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ISPD
Protein name RecName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;
AltName: Full=4-diphosphocytidyl-2C-methyl-D-erythritol synthase;
AltName: Full=MEP cytidylyltransferase;
Gene name Name=ispD;

Comments [?]

FUNCTIONCatalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
CATALYTIC ACTIVITY Reaction=2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C- methyl-D-erythritol + diphosphate; Xref=Rhea:RHEA:13429, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:57823, ChEBI:CHEBI:58262; EC=;
PATHWAYIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5- phosphate: step 2/6.
case <OC:Enterobacterales>
end case
SIMILARITYBelongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0050518; Molecular function:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO:0016114; Biological process:terpenoid biosynthetic process

Cross-references [?]

Pfam PF01128; IspD; 1;
NCBIfam TIGR00453; IspD; 1;

Features [?]

From: ISPD_ECOLI (Q46893)
Key From To Description Tag Condition FTGroup
SITE 20 20 /note="Transition state stabilizer" R
SITE 27 27 /note="Transition state stabilizer" K
SITE 157 157 /note="Positions MEP for the nucleophilic attack" R
SITE 213 213 /note="Positions MEP for the nucleophilic attack" K

Additional information [?]

Size range 211-291 amino acids
Related rules MF_01520
Fusion Nter: None Cter: None
Comments See MF_01520 for bifunctional ispDF

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