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Annotation rule MF_00108
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General rule information [?]

Accession MF_00108
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 32)
Name IspD
Scope
Bacteria
Template Q46893 (ISPD_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ISPD
Protein name
RecName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;
EC 2.7.7.60;
AltName: Full=4-diphosphocytidyl-2C-methyl-D-erythritol synthase;
AltName: Full=MEP cytidylyltransferase;
Short=MCT;
Gene name
ispD

Comments [?]

Function Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity RHEA:13429: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate
EC 2.7.7.60
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
case <OC:Enterobacterales>
Subunit Homodimer.
end case
Similarity Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.

Keywords [?]

Isoprene biosynthesis
Nucleotidyltransferase
Transferase

Gene Ontology [?]

GO:0050518; Molecular function: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.

Cross-references [?]

Pfam PF01128; IspD; 1;
TIGRFAMs TIGR00453; IspD; 1;
PROSITE PS01295; ISPD; 1;

Features [?]

From: ISPD_ECOLI (Q46893)
Key     From     To       Description   Tag   Condition   FTGroup
SITE     20     20       Transition state stabilizer     R  
SITE     27     27       Transition state stabilizer     K  
SITE     157     157       Positions MEP for the nucleophilic attack     R  
SITE     213     213       Positions MEP for the nucleophilic attack     K  

Additional information [?]

Size range 211-291 amino acids
Related rules MF_01520 (ISPDF supersedes the current rule)
Fusion None
Comments See MF_01520 for bifunctional ispDF


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