HAMAP rule MF_00111
General rule information
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| Accession | MF_00111 |
| Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 55) |
| Name | MurA |
| Scope(s) |
Bacteria |
| Template(s) | P0A749 (MURA_ECOLI); P33038 (MURA_ENTCC); [ Recover all ] |
| Triggered by |
HAMAP; MF_00111 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MURA |
| Protein name | RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase; EC=2.5.1.7; AltName: Full=Enoylpyruvate transferase; AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase; Short=EPT; |
| Gene name | Name=murA; |
Comments
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| FUNCTION | Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. |
| CATALYTIC ACTIVITY | Reaction=phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine; Xref=Rhea:RHEA:18681, ChEBI:CHEBI:43474, ChEBI:CHEBI:57705, ChEBI:CHEBI:58702, ChEBI:CHEBI:68483; EC=2.5.1.7; |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the EPSP synthase family. MurA subfamily. |
Keywords
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| Cell cycle | |
| Cell division | |
| Cell shape | |
| Cell wall biogenesis/degradation | |
| Cytoplasm | |
| Peptidoglycan synthesis | |
| case <FTTag:pyruvyl> | |
| Pyruvate | |
| end case | |
| Transferase | |
Gene Ontology
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| GO:0008760; Molecular function:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity |
| GO:0009252; Biological process:peptidoglycan biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: MURA_ECOLI (P0A749) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 22 | 23 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
K-N | ||||||||
| BINDING | 120 | 124 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705" |
R-P-[VILM]-[DE]-[LQ] | ||||||||
| BINDING | 160 | 163 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705" |
K-V-S-V | ||||||||
| ACT_SITE | 115 | 115 | /note="Proton donor" | [CD] | ||||||||
| BINDING | 91 | 91 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705" |
R | ||||||||
| BINDING | 305 | 305 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705" |
D | ||||||||
| BINDING | 327 | 327 | /ligand="UDP-N-acetyl-alpha-D-glucosamine" /ligand_id="ChEBI:CHEBI:57705" |
[VILM] | ||||||||
| MOD_RES | 115 | 115 | /note="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" | pyruvyl | C | |||||||
Additional information
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| Size range | 350-535 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Longer C-terminus in one copy in LEGPL; not included in size range |