HAMAP logo

HAMAP rule MF_00111

Send feedback

General rule information [?]

Accession MF_00111
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 55)
Name MurA
Scope(s) Bacteria
Template(s) P0A749 (MURA_ECOLI); P33038 (MURA_ENTCC); [ Recover all ]
Triggered by HAMAP; MF_00111 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MURA
Protein name RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase;
AltName: Full=Enoylpyruvate transferase;
AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase;
Gene name Name=murA;

Comments [?]

FUNCTIONCell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine.
CATALYTIC ACTIVITY Reaction=phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine; Xref=Rhea:RHEA:18681, ChEBI:CHEBI:43474, ChEBI:CHEBI:57705, ChEBI:CHEBI:58702, ChEBI:CHEBI:68483; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
SIMILARITYBelongs to the EPSP synthase family. MurA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008760; Molecular function:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00275; EPSP_synthase; 1;
NCBIfam TIGR01072; MurA; 1;

Features [?]

From: MURA_ECOLI (P0A749)
Key From To Description Tag Condition FTGroup
BINDING 22 23 /ligand="phosphoenolpyruvate"
BINDING 120 124 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
BINDING 160 163 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
ACT_SITE 115 115 /note="Proton donor" [CD]
BINDING 91 91 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
BINDING 305 305 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
BINDING 327 327 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
MOD_RES 115 115 /note="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" pyruvyl C

Additional information [?]

Size range 350-535 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Longer C-terminus in one copy in LEGPL; not included in size range

View rule in raw text format (no links)