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Annotation rule MF_00111
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General rule information [?]

Accession MF_00111
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 46)
Name MurA
Scope
Bacteria
Templates P0A749 (MURA_ECOLI); P33038 (MURA_ENTCC): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MURA
Protein name
RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase;
EC 2.5.1.7;
AltName: Full=Enoylpyruvate transferase;
AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase;
Short=EPT;
Gene name
murA

Comments [?]

Function Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Catalytic activity RHEA:18681: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
EC 2.5.1.7
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location Cytoplasm.
Similarity Belongs to the EPSP synthase family. MurA subfamily.

Keywords [?]

Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Peptidoglycan synthesis
case <FTTag:pyruvyl>
Pyruvate
end case
Transferase

Gene Ontology [?]

GO:0008760; Molecular function: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00275; EPSP_synthase; 1;
TIGRFAMs TIGR01072; MurA; 1;

Features [?]

From: MURA_ECOLI (P0A749)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     22     23       Phosphoenolpyruvate binding     K-N  
REGION (Optional)     120     124       UDP-N-acetylglucosamine binding     R-P-[VILM]-[DE]-[LQ]  
REGION (Optional)     160     163       UDP-N-acetylglucosamine binding     K-V-S-V  
ACT_SITE     115     115       Proton donor     [CD]  
BINDING (Optional)     91     91       UDP-N-acetylglucosamine     R  
BINDING (Optional)     305     305       UDP-N-acetylglucosamine     D  
BINDING (Optional)     327     327       UDP-N-acetylglucosamine; via carbonyl oxygen     [VILM]  
MOD_RES (Optional)     115     115       2-(S-cysteinyl)pyruvic acid O-phosphothioketal   pyruvyl   C  

Additional information [?]

Size range 350-535 amino acids
Related rules None
Fusion None
Comments Longer C-terminus in one copy in LEGPL; not included in size range


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