HAMAP rule MF_00113

General rule information [?]

Accession	MF_00113
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 30)

Name

QueA

Scope

Bacteria

Templates

P0A7F9 (QUEA_ECOLI); A8AYK5 (QUEA_STRGC): [Recover all]

Triggered by

HAMAP; MF_00113 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

QUEA

Protein name

RecName:		Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase;
		EC 2.4.99.17;
AltName:		Full=Queuosine biosynthesis protein QueA;

Gene name

queA

Comments [?]

Function	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Catalytic activity	RHEA:32155: 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine EC 2.4.99.17
Pathway	tRNA modification; tRNA-queuosine biosynthesis.
Subunit	Monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the QueA family.

Keywords [?]

Cytoplasm
Queuosine biosynthesis
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0016853; Molecular function: isomerase activity.
GO:0016740; Molecular function: transferase activity.
GO:0008616; Biological process: queuosine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02547; Queuosine_synth; 1;
NCBIfam	TIGR00113; QueA; 1;

Additional information [?]

Size range	334-408 amino acids
Related rules	None
Fusion	None
Comments	RPE-type insertion in RICCN and RICPR. Probable wrong start in NOSS1 and DEIRA.

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