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HAMAP rule MF_00113

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General rule information [?]

Accession MF_00113
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 30)
Name QueA
Templates P0A7F9 (QUEA_ECOLI); A8AYK5 (QUEA_STRGC): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase;
AltName: Full=Queuosine biosynthesis protein QueA;
Gene name

Comments [?]

Function Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Catalytic activity RHEA:32155: 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine
Pathway tRNA modification; tRNA-queuosine biosynthesis.
Subunit Monomer.
Subcellular location Cytoplasm.
Similarity Belongs to the QueA family.

Keywords [?]

Gene Ontology [?]

GO:0016853; Molecular function: isomerase activity.
GO:0016740; Molecular function: transferase activity.
GO:0008616; Biological process: queuosine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02547; Queuosine_synth; 1;
NCBIfam TIGR00113; QueA; 1;

Additional information [?]

Size range 334-408 amino acids
Related rules None
Fusion None
Comments RPE-type insertion in RICCN and RICPR. Probable wrong start in NOSS1 and DEIRA.