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HAMAP rule MF_00113

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General rule information [?]

Accession MF_00113
Dates 1-JUN-2001 (Created)
31-JAN-2024 (Last updated, Version 31)
Name QueA
Scope(s) Bacteria
Template(s) P0A7F9 (QUEA_ECOLI); A8AYK5 (QUEA_STRGC); [ Recover all ]
Triggered by HAMAP; MF_00113 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier QUEA
Protein name RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase;
AltName: Full=Queuosine biosynthesis protein QueA;
Gene name Name=queA;

Comments [?]

FUNCTIONTransfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
CATALYTIC ACTIVITY Reaction=7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L- methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L- methionine; Xref=Rhea:RHEA:32155, Rhea:RHEA-COMP:10342, Rhea:RHEA- COMP:18582, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:82833, ChEBI:CHEBI:194443; EC=;
PATHWAYtRNA modification; tRNA-queuosine biosynthesis.
SIMILARITYBelongs to the QueA family.

Keywords [?]

Gene Ontology [?]

GO:0016853; Molecular function:isomerase activity
GO:0016740; Molecular function:transferase activity
GO:0008616; Biological process:queuosine biosynthetic process
GO:0006400; Biological process:tRNA modification
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02547; Queuosine_synth; 1;
NCBIfam TIGR00113; QueA; 1;

Features [?]

Additional information [?]

Size range 334-408 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments RPE-type insertion in RICCN and RICPR. Probable wrong start in NOSS1 and DEIRA.

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