HAMAP rule MF_00113
General rule information
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| Accession | MF_00113 |
| Dates | 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 32) |
| Name | QueA |
| Scope(s) |
Bacteria |
| Template(s) | P0A7F9 (QUEA_ECOLI); A8AYK5 (QUEA_STRGC); [ Recover all ] |
| Triggered by |
HAMAP; MF_00113 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | QUEA |
| Protein name | RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase; EC=2.4.99.17; AltName: Full=Queuosine biosynthesis protein QueA; |
| Gene name | Name=queA; |
Comments
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| FUNCTION | Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). |
| CATALYTIC ACTIVITY | Reaction=7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L- methionine = epoxyqueuosine(34) in tRNA + adenine + L-methionine + 2 H(+); Xref=Rhea:RHEA:32155, Rhea:RHEA-COMP:10342, Rhea:RHEA- COMP:18582, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:82833, ChEBI:CHEBI:194443; EC=2.4.99.17; |
| PATHWAY | tRNA modification; tRNA-queuosine biosynthesis. |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the QueA family. |
Keywords
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Gene Ontology
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| GO:0016853; Molecular function:isomerase activity |
| GO:0016740; Molecular function:transferase activity |
| GO:0008616; Biological process:queuosine biosynthetic process |
| GO:0006400; Biological process:tRNA modification |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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Additional information
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| Size range | 334-408 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | RPE-type insertion in RICCN and RICPR. Probable wrong start in NOSS1 and DEIRA. |