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HAMAP rule MF_00115

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General rule information [?]

Accession MF_00115
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 48)
Name MscL
Scope(s) Bacteria
Template(s) P0A742 (MSCL_ECOLI); P9WJN5 (MSCL_MYCTU); P68806 (MSCL_STAAW); P94585 (MSCL_BACSU); O68284 (MSCL_PECCA); P44789 (MSCL_HAEIN); P68805 (MSCL_STAA8); [ Recover all ]
Triggered by HAMAP; MF_00115 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MSCL
Protein name RecName: Full=Large-conductance mechanosensitive channel;
Gene name Name=mscL;

Comments [?]

FUNCTIONChannel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the MscL family.

Keywords [?]

case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
Cell inner membrane
end case
Cell membrane
Ion channel
Ion transport
Transmembrane helix

Gene Ontology [?]

GO:0008381; Molecular function:mechanosensitive monoatomic ion channel activity
GO:0034220; Biological process:monoatomic ion transmembrane transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01741; MscL; 1;
NCBIfam TIGR00220; MscL; 1;
General Transmembrane; -; 2-3;

Features [?]

Additional information [?]

Size range 100-220 amino acids
Related rules None
Fusion Nter: None Cter: None

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