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HAMAP rule MF_00115

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General rule information [?]

Accession MF_00115
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 48)
Name MscL
Scope
Bacteria
Templates P0A742 (MSCL_ECOLI); P9WJN5 (MSCL_MYCTU); P68806 (MSCL_STAAW); P94585 (MSCL_BACSU); O68284 (MSCL_PECCA); P44789 (MSCL_HAEIN); P68805 (MSCL_STAA8): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MSCL
Protein name
RecName: Full=Large-conductance mechanosensitive channel;
Gene name
mscL

Comments [?]

Function Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Subunit Homopentamer.
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
Subcellular location Cell inner membrane; Multi-pass membrane protein.
else
Subcellular location Cell membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the MscL family.

Keywords [?]

case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
Cell inner membrane
end case
Cell membrane
Ion channel
Ion transport
Membrane
Transmembrane
Transport
Transmembrane helix

Gene Ontology [?]

GO:0008381; Molecular function: mechanosensitive monoatomic ion channel activity.
GO:0034220; Biological process: monoatomic ion transmembrane transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01741; MscL; 1;
NCBIfam TIGR00220; MscL; 1;
PROSITE PS01327; MSCL; 1;

Computed features [?]

General Transmembrane; -; 2-3; trigger=yes;

Additional information [?]

Size range 100-220 amino acids
Related rules None
Fusion None
Comments None.


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