HAMAP rule MF_00116
General rule information
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Accession | MF_00116 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 32) |
Name | dUTPase_bact |
Scope | Bacteria |
Templates | P06968 (DUT_ECOLI); P9WNS5 (DUT_MYCTU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. |
Catalytic activity | RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23 |
Cofactor | Mg(2+) |
Pathway | Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. |
case <OC:Escherichia> or <OC:Mycobacterium>
Subunit | Homotrimer. |
end case
Similarity | Belongs to the dUTPase family. |
Keywords
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Gene Ontology
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GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
Cross-references
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Features
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From: DUT_ECOLI (P06968) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 71 | 73 | /ligand="substrate | R-S-[GS] | ||||||||
BINDING (Optional) | 88 | 90 | /ligand="substrate | [TVL]-[IV]-D | ||||||||
BINDING (Optional) | 84 | 84 | /ligand="substrate | [NQ] |
case not <FT:2>
end case
Additional information
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Size range | 139-185 amino acids |
Related rules | None |
Fusion | None |