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Annotation rule MF_00116 |
General rule information
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Accession |
MF_00116 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 29) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
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Short=dUTPase;
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EC 3.6.1.23;
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AltName:
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Full=dUTP pyrophosphatase;
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Function |
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. |
Catalytic activity |
RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23
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Cofactor |
Mg(2+) |
Pathway |
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. |
case <OC:Escherichia> or <OC:Mycobacterium>
end case
Similarity |
Belongs to the dUTPase family. |
GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
From: DUT_ECOLI (P06968) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION (Optional)
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71
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73
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Substrate binding
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R-S-[GS]
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REGION (Optional)
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88
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90
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Substrate binding
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[TVL]-[IV]-D
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BINDING (Optional)
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84
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84
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Substrate
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[NQ]
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case not <FT:2>
BINDING (Optional)
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90
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90
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Substrate
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D
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end case
BINDING (Optional)
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96
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96
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Substrate; via amide nitrogen and carbonyl oxygen
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[KM]
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Additional information
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Size range |
139-185 amino acids |
Related rules |
None |
Fusion |
None |