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HAMAP rule MF_00116

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General rule information [?]

Accession MF_00116
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name dUTPase_bact
Scope
Bacteria
Templates P06968 (DUT_ECOLI); P9WNS5 (DUT_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DUT
Protein name
RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
Short=dUTPase;
EC 3.6.1.23;
AltName: Full=dUTP pyrophosphatase;
Gene name
dut

Comments [?]

Function This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23
Cofactor Mg(2+)
Pathway Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
case <OC:Escherichia> or <OC:Mycobacterium>
Subunit Homotrimer.
end case
Similarity Belongs to the dUTPase family.

Keywords [?]

Hydrolase
Magnesium
Metal-binding
Nucleotide metabolism

Gene Ontology [?]

GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.

Cross-references [?]

Pfam PF00692; dUTPase; 1;
NCBIfam TIGR00576; Dut; 1;

Features [?]

From: DUT_ECOLI (P06968)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     71     73       /ligand="substrate     R-S-[GS]  
BINDING (Optional)     88     90       /ligand="substrate     [TVL]-[IV]-D  
BINDING (Optional)     84     84       /ligand="substrate     [NQ]  
case not <FT:2>
BINDING (Optional)     90     90       /ligand="substrate     D  
end case
BINDING (Optional)     96     96       /ligand="substrate     [KM]  

Additional information [?]

Size range 139-185 amino acids
Related rules None
Fusion None


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