HAMAP rule MF_00116

General rule information [?]

Accession	MF_00116
Dates	1-JUN-2001 (Created) 25-JAN-2024 (Last updated, Version 33)
Name	dUTPase_bact
Scope(s)	Bacteria
Template(s)	P06968 (DUT_ECOLI); P9WNS5 (DUT_MYCTU); [ Recover all ]
Triggered by	HAMAP; MF_00116 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DUT
Protein name	RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase; Short=dUTPase; EC=3.6.1.23; AltName: Full=dUTP pyrophosphatase;
Gene name	Name=dut;

Comments [?]

FUNCTION	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
CATALYTIC ACTIVITY	Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAY	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
case <OC:Escherichia> or <OC:Mycobacterium>
SUBUNIT	Homotrimer.
end case
SIMILARITY	Belongs to the dUTPase family.

Keywords [?]

Gene Ontology [?]

GO:0004170; Molecular function:dUTP diphosphatase activity

GO:0000287; Molecular function:magnesium ion binding

GO:0006226; Biological process:dUMP biosynthetic process

Cross-references [?]

Pfam	PF00692; dUTPase; 1;
NCBIfam	TIGR00576; Dut; 1;

Features [?]

From: DUT_ECOLI (P06968)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="substrate"

R-S-[GS]

BINDING

/ligand="substrate"

[TVL]-[IV]-D

BINDING

/ligand="substrate"

[NQ]

case not <FT:2>

BINDING

/ligand="substrate"

end case

BINDING

/ligand="substrate"

[KM]

Additional information [?]