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HAMAP rule MF_00124

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General rule information [?]

Accession MF_00124
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 24)
Name Thymidine_kinase
Scope(s) Archaea
Template(s) Q97F65 (KITH_CLOAB); Q9PPP5 (KITH_UREPA); P23331 (KITH_ECOLI); Q81JX0 (KITH_BACAN); Q814U0 (KITH_BACCR); Q9WYN2 (KITH_THEMA); [ Recover all ]
Triggered by HAMAP; MF_00124 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KITH
Protein name RecName: Full=Thymidine kinase;
Gene name Name=tdk;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=;
SIMILARITYBelongs to the thymidine kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004797; Molecular function:thymidine kinase activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0006259; Biological process:DNA metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00265; TK; 1;

Features [?]

From: KITH_CLOAB (Q97F65)
Key From To Description Tag Condition FTGroup
BINDING 15 22 /ligand="ATP"
BINDING 88 91 /ligand="ATP"
ACT_SITE 89 89 /note="Proton acceptor" E
BINDING 145 145 /ligand="Zn(2+)"
C 1
BINDING 148 148 /ligand="Zn(2+)"
C 1
BINDING 183 183 /ligand="Zn(2+)"
C 1
BINDING 186 186 /ligand="Zn(2+)"
[CH] 1

Additional information [?]

Size range 184-227 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments There is a divergent tdk in a Bacillus natto plasmid (O52951)

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