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Annotation rule MF_00124
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General rule information [?]

Accession MF_00124
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 22)
Name Thymidine_kinase
Scope
Archaea
Bacteria
Templates Q97F65 (KITH_CLOAB); Q9PPP5 (KITH_UREPA); P23331 (KITH_ECOLI); Q81JX0 (KITH_BACAN); Q814U0 (KITH_BACCR); Q9WYN2 (KITH_THEMA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KITH
Protein name
RecName: Full=Thymidine kinase;
EC 2.7.1.21;
Gene name
tdk

Comments [?]

Catalytic activity RHEA:19129: ATP + thymidine = ADP + dTMP + H(+)
EC 2.7.1.21
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the thymidine kinase family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004797; Molecular function: thymidine kinase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0006259; Biological process: DNA metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00265; TK; 1;
PROSITE PS00603; TK_CELLULAR_TYPE; 1;

Features [?]

From: KITH_CLOAB (Q97F65)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     15     22       ATP     [GSA]-x(4)-G-K-[ST]  
NP_BIND     88     91       ATP     [DE]-E-x-[QHN]  
ACT_SITE     89     89       Proton acceptor     E  
METAL (Optional)     145     145       Zinc     C   1
METAL (Optional)     148     148       Zinc     C   1
METAL (Optional)     183     183       Zinc     C   1
METAL (Optional)     186     186       Zinc     [CH]   1

Additional information [?]

Size range 184-227 amino acids
Related rules None
Fusion None
Comments There is a divergent tdk in a Bacillus natto plasmid (O52951)