HAMAP logo

HAMAP rule MF_00125

Send feedback

General rule information [?]

Accession MF_00125
Dates 3-MAY-2002 (Created)
1-JUN-2023 (Last updated, Version 33)
Name HisZ
Scope(s) Bacteria
Template(s) Q02147 (HISZ_LACLA); [ Recover all ]
Triggered by HAMAP; MF_00125 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HISZ
Protein name RecName: Full=ATP phosphoribosyltransferase regulatory subunit;
Gene name Name=hisZ;

Comments [?]

FUNCTIONRequired for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
SUBUNITHeteromultimer composed of HisG and HisZ subunits.
MISCELLANEOUSThis function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
SIMILARITYBelongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00587; tRNA-synt_2b; 1;
NCBIfam TIGR00443; HisZ_biosyn_reg; 1;

Features [?]

Additional information [?]

Size range 270-438 amino acids
Related rules MF_00127
Fusion Nter: None Cter: None
Comments Difficulty to distinguish between hisS and hisZ families.

View rule in raw text format (no links)