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Annotation rule MF_00125
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General rule information [?]

Accession MF_00125
Dates 3-MAY-2002 (Created)
18-NOV-2019 (Last updated, Version 32)
Name HisZ
Scope
Bacteria
Template Q02147 (HISZ_LACLA)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HISZ
Protein name
RecName: Full=ATP phosphoribosyltransferase regulatory subunit;
Gene name
hisZ

Comments [?]

Function Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
Subunit Heteromultimer composed of HisG and HisZ subunits.
Subcellular location Cytoplasm.
Miscellaneous This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Similarity Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00587; tRNA-synt_2b; 1;
TIGRFAMs TIGR00443; HisZ_biosyn_reg; 1;
PROSITE PS50862; AA_TRNA_LIGASE_II; 0-1;

Additional information [?]

Size range 270-438 amino acids
Related rules MF_00127 (SYH supersedes the current rule)
Fusion None
Comments Difficulty to distinguish between hisS and hisZ families.