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| Annotation rule MF_00125 |
General rule information
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| Accession | MF_00125 |
| Dates | 3-MAY-2002 (Created) 18-NOV-2019 (Last updated, Version 32) |
| Name | HisZ |
| Scope | Bacteria |
| Template | Q02147 (HISZ_LACLA) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. |
| Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. |
| Subunit | Heteromultimer composed of HisG and HisZ subunits. |
| Subcellular location | Cytoplasm. |
| Miscellaneous | This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. |
| Similarity | Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily. |
Keywords
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Gene Ontology
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GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00587; tRNA-synt_2b; 1; |
| TIGRFAMs | TIGR00443; HisZ_biosyn_reg; 1; |
| PROSITE | PS50862; AA_TRNA_LIGASE_II; 0-1; |
Additional information
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| Size range | 270-438 amino acids |
| Related rules | MF_00127 (SYH supersedes the current rule) |
| Fusion | None |
| Comments | Difficulty to distinguish between hisS and hisZ families. |