HAMAP rule MF_00125
General rule information
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| Accession | MF_00125 |
| Dates | 3-MAY-2002 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | HisZ |
| Scope(s) |
Bacteria |
| Template(s) | Q02147 (HISZ_LACLA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00125 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HISZ |
| Protein name | RecName: Full=ATP phosphoribosyltransferase regulatory subunit; |
| Gene name | Name=hisZ; |
Comments
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| FUNCTION | Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. |
| SUBUNIT | Heteromultimer composed of HisG and HisZ subunits. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| MISCELLANEOUS | This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. |
| SIMILARITY | Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily. |
Keywords
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Gene Ontology
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| GO:0000105; Biological process:histidine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00587; tRNA-synt_2b; 1; |
| NCBIfam | TIGR00443; HisZ_biosyn_reg; 1; |
| PROSITE | PS50862; AA_TRNA_LIGASE_II; 0-1; |
Features
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Additional information
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| Size range | 270-438 amino acids |
| Related rules |
MF_00127 |
| Fusion | Nter: None Cter: None |
| Comments | Difficulty to distinguish between hisS and hisZ families. |