![]() |
|
Annotation rule MF_00125 |
Accession | MF_00125 |
Dates | 3-MAY-2002 (Created) 18-NOV-2019 (Last updated, Version 32) |
Name | HisZ |
Scope | Bacteria |
Template | Q02147 (HISZ_LACLA) |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. |
Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. |
Subunit | Heteromultimer composed of HisG and HisZ subunits. |
Subcellular location | Cytoplasm. |
Miscellaneous | This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. |
Similarity | Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily. |
Pfam | PF00587; tRNA-synt_2b; 1; |
TIGRFAMs | TIGR00443; HisZ_biosyn_reg; 1; |
PROSITE | PS50862; AA_TRNA_LIGASE_II; 0-1; |
Size range | 270-438 amino acids |
Related rules | MF_00127 (SYH supersedes the current rule) |
Fusion | None |
Comments | Difficulty to distinguish between hisS and hisZ families. |