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Annotation rule MF_00136
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General rule information [?]

Accession MF_00136
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 30)
Name S_AdoMet_synth2
Scope
Bacteria
Archaea
Template Q58605 (METK_METJA)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier
METK
Protein name
RecName: Full=S-adenosylmethionine synthase;
Short=AdoMet synthase;
EC 2.5.1.6;
AltName: Full=Methionine adenosyltransferase;
end case
case <OC:Bacteria>
Identifier
METL
Protein name
RecName: Full=Probable S-adenosylmethionine synthase;
Short=AdoMet synthase;
EC 2.5.1.6;
AltName: Full=Methionine adenosyltransferase;
end case
Gene name
mat

Comments [?]

Function Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Catalytic activity RHEA:21080: ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine
EC 2.5.1.6
Cofactor Mg(2+)
Pathway Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
Similarity Belongs to the AdoMet synthase 2 family.

Keywords [?]

Transferase
One-carbon metabolism
ATP-binding
Nucleotide-binding
Magnesium

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004478; Molecular function: methionine adenosyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.

Cross-references [?]

Pfam PF01941; AdoMet_Synthase; 1;

Features [?]

From: METK_METJA (Q58605)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     141     146       ATP     [GK]-x-G-S-x-D  

Additional information [?]

Size range 397-410 amino acids
Related rules None
Fusion None
Comments AQUAE seems to have 2 copies of S-adenosylmethionine synthase, one (O67222) belonging to the S-adenosylmethionine synthase type 1 family (MF_00086) and the other (O67275) matching the type 2 family (this HAMAP rule).


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