HAMAP rule MF_00136
General rule information
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| Accession | MF_00136 |
| Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 32) |
| Name | S_AdoMet_synth2 |
| Scope | Bacteria
Archaea |
| Template | Q58605 (METK_METJA) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Archaea>
| Identifier |
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| Protein name |
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end case
case <OC:Bacteria>
| Identifier |
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| Protein name |
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end case
| Gene name |
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Comments
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| Function | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. |
| Catalytic activity | RHEA:21080: ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine
EC 2.5.1.6 |
| Cofactor | Mg(2+) |
| Pathway | Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. |
| Similarity | Belongs to the AdoMet synthase 2 family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004478; Molecular function: methionine adenosyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004478; Molecular function: methionine adenosyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
Cross-references
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| Pfam | PF01941; AdoMet_Synthase; 1; |
Features
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| From: METK_METJA (Q58605) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 141 | 146 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [GK]-x-G-S-x-D | ||||||||
Additional information
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| Size range | 397-410 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | AQUAE seems to have 2 copies of S-adenosylmethionine synthase, one (O67222) belonging to the S-adenosylmethionine synthase type 1 family (MF_00086) and the other (O67275) matching the type 2 family (this HAMAP rule). |