HAMAP rule MF_00136

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00136
Accession	MF_00136
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 27)
Name	S_AdoMet_synth2
Scope(s)	Bacteria Archaea
Template(s)	Q58605; [ Recover all ]
Triggered by	HAMAP; MF_00136 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier	METK
Protein name	RecName: Full=S-adenosylmethionine synthase; Short=AdoMet synthase; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase;
end case
case <OC:Bacteria>
Identifier	METL
Protein name	RecName: Full=Probable S-adenosylmethionine synthase; Short=AdoMet synthase; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase;
end case
Gene name	Name=mat;

Comments [?]

FUNCTION	Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
CATALYTIC ACTIVITY	Reaction=L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate; Xref=Rhea:RHEA:21080, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789; EC=2.5.1.6;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAY	Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
SIMILARITY	Belongs to the AdoMet synthase 2 family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0000287; Molecular function:magnesium ion binding

GO:0004478; Molecular function:methionine adenosyltransferase activity

GO:0006556; Biological process:S-adenosylmethionine biosynthetic process

Cross-references [?]

Pfam	PF01941; AdoMet_Synthase; 1;

Features [?]

From: METK_METJA (Q58605)

Key

From

Description

Tag

Condition

FTGroup

BINDING

141

146

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

[GK]-x-G-S-x-D

Additional information [?]

Size range	397-410 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	AQUAE seems to have 2 copies of S-adenosylmethionine synthase, one (O67222) belonging to the S-adenosylmethionine synthase type 1 family (MF_00086) and the other (O67275) matching the type 2 family (this HAMAP rule).