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HAMAP rule MF_00136

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General rule information [?]

Accession MF_00136
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 32)
Name S_AdoMet_synth2
Scope(s) Bacteria
Template(s) Q58605 (METK_METJA); [ Recover all ]
Triggered by HAMAP; MF_00136 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier METK
Protein name RecName: Full=S-adenosylmethionine synthase;
                 Short=AdoMet synthase;
AltName: Full=Methionine adenosyltransferase;
end case
case <OC:Bacteria>
Identifier METL
Protein name RecName: Full=Probable S-adenosylmethionine synthase;
                 Short=AdoMet synthase;
AltName: Full=Methionine adenosyltransferase;
end case
Gene name Name=mat;

Comments [?]

FUNCTIONCatalyzes the formation of S-adenosylmethionine from methionine and ATP.
CATALYTIC ACTIVITY Reaction=ATP + H2O + L-methionine = diphosphate + phosphate + S- adenosyl-L-methionine; Xref=Rhea:RHEA:21080, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYAmino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
SIMILARITYBelongs to the AdoMet synthase 2 family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0000287; Molecular function:magnesium ion binding
GO:0004478; Molecular function:methionine adenosyltransferase activity
GO:0006730; Biological process:one-carbon metabolic process

Cross-references [?]

Pfam PF01941; AdoMet_Synthase; 1;

Features [?]

From: METK_METJA (Q58605)
Key From To Description Tag Condition FTGroup
BINDING 141 146 /ligand="ATP"

Additional information [?]

Size range 397-410 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments AQUAE seems to have 2 copies of S-adenosylmethionine synthase, one (O67222) belonging to the S-adenosylmethionine synthase type 1 family (MF_00086) and the other (O67275) matching the type 2 family (this HAMAP rule).

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