HAMAP rule MF_00137

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00137
Accession	MF_00137
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 27)
Name	SAICAR_synth
Scope(s)	Bacteria Archaea
Template(s)	P0A7D7; [ Recover all ]
Triggered by	HAMAP; MF_00137 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PUR7
Protein name	RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase; EC=6.3.2.6; AltName: Full=SAICAR synthetase;
Gene name	Name=purC;

Comments [?]

CATALYTIC ACTIVITY	Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L- aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+); Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443, ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
PATHWAY	Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
SIMILARITY	Belongs to the SAICAR synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0004639; Molecular function:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Features [?]

Additional information [?]

Size range	216-367 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	Highly divergent ARCFU and HALSA; sequences not included in alignment. Seems to be absent in AERPE. Some of the Alphaproteobacteria have a possible second copy.