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Annotation rule MF_00137
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General rule information [?]

Accession MF_00137
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 38)
Name SAICAR_synth
Scope
Bacteria
Archaea
Template P0A7D7 (PUR7_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PUR7
Protein name
RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
EC 6.3.2.6;
AltName: Full=SAICAR synthetase;
Gene name
purC

Comments [?]

Catalytic activity RHEA:22628: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate
EC 6.3.2.6
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
Similarity Belongs to the SAICAR synthetase family.

Keywords [?]


Gene Ontology [?]

GO:0004639; Molecular function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam PF01259; SAICAR_synt; 1;
TIGRFAMs TIGR00081; purC; 1;
TIGR02735; purC_vibrio; 0-1;
PROSITE PS01057; SAICAR_SYNTHETASE_1; 1;
PS01058; SAICAR_SYNTHETASE_2; 1;

Additional information [?]

Size range 216-367 amino acids
Related rules None
Fusion None
Comments Highly divergent ARCFU and HALSA; sequences not included in alignment. Seems to be absent in AERPE. Some of the Alphaproteobacteria have a possible second copy.