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HAMAP rule MF_00150

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General rule information [?]

Accession MF_00150
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 44)
Name ArgC_type1
Scope(s) Bacteria
Template(s) P11446 (ARGC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00150 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARGC
Protein name RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase;
AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase;
                 Short=NAGSA dehydrogenase;
Gene name Name=argC;

Comments [?]

FUNCTIONCatalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
CATALYTIC ACTIVITY Reaction=N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH; Xref=Rhea:RHEA:21588, ChEBI:CHEBI:15378, ChEBI:CHEBI:29123, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:57936, ChEBI:CHEBI:58349; EC=;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 3/4.
SIMILARITYBelongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003942; Molecular function:N-acetyl-gamma-glutamyl-phosphate reductase activity
GO:0006526; Biological process:arginine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01118; Semialdhyde_dh; 1;
NCBIfam TIGR01850; argC; 1;

Features [?]

From: ARGC_ECOLI (P11446)
Key From To Description Tag Condition FTGroup
ACT_SITE 154 154 C

Additional information [?]

Size range 308-364 amino acids
Related rules MF_02083
Fusion Nter: None Cter: None
Comments See MF_01110 for ArgC type 2 subfamily. MF_00150 also matches LysY, which is a subfamily of ArgC type 1. MF_02083 is a child of MF_00150 and is specific for LysY.

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