HAMAP rule MF_00150

General rule information [?]

Accession	MF_00150
Dates	1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 43)

Name	ArgC_type1

Scope

Bacteria

Archaea

Template

P11446 (ARGC_ECOLI)

Triggered by

HAMAP; MF_00150 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ARGC

Protein name

RecName:		Full=N-acetyl-gamma-glutamyl-phosphate reductase;
		Short=AGPR;
		EC 1.2.1.38;
AltName:		Full=N-acetyl-glutamate semialdehyde dehydrogenase;
		Short=NAGSA dehydrogenase;

Gene name

argC

Comments [?]

Function	Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
Catalytic activity	RHEA:21588: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH EC 1.2.1.38
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.
Subcellular location	Cytoplasm.
Similarity	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
Oxidoreductase
NADP

Gene Ontology [?]

GO:0003942; Molecular function: N-acetyl-gamma-glutamyl-phosphate reductase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01118; Semialdhyde_dh; 1;
PROSITE	PS01224; ARGC; 1;
TIGRFAMs	TIGR01850; argC; 1;

Features [?]

From: ARGC_ECOLI (P11446)

Key From To Description Tag Condition FTGroup

ACT_SITE 154 154 C

Additional information [?]

Size range	308-364 amino acids
Related rules	MF_02083 (LYSY supersedes the current rule)
Fusion	None
Comments	See MF_01110 for ArgC type 2 subfamily. MF_00150 also matches LysY, which is a subfamily of ArgC type 1. MF_02083 is a child of MF_00150 and is specific for LysY.

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