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Annotation rule MF_00150
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General rule information [?]

Accession MF_00150
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 43)
Name ArgC_type1
Scope
Bacteria
Archaea
Template P11446 (ARGC_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ARGC
Protein name
RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase;
Short=AGPR;
EC 1.2.1.38;
AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase;
Short=NAGSA dehydrogenase;
Gene name
argC

Comments [?]

Function Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
Catalytic activity RHEA:21588: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH
EC 1.2.1.38
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.
Subcellular location Cytoplasm.
Similarity Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
Oxidoreductase
NADP

Gene Ontology [?]

GO:0003942; Molecular function: N-acetyl-gamma-glutamyl-phosphate reductase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01118; Semialdhyde_dh; 1;
PROSITE PS01224; ARGC; 1;
TIGRFAMs TIGR01850; argC; 1;

Features [?]

From: ARGC_ECOLI (P11446)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     154     154             C  

Additional information [?]

Size range 308-364 amino acids
Related rules MF_02083 (LYSY supersedes the current rule)
Fusion None
Comments See MF_01110 for ArgC type 2 subfamily. MF_00150 also matches LysY, which is a subfamily of ArgC type 1. MF_02083 is a child of MF_00150 and is specific for LysY.


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