HAMAP rule MF_00152
General rule information
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| Accession | MF_00152 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | Nfo |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A6C1 (END4_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00152 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | END4 |
| Protein name | RecName: Full=Probable endonuclease 4; EC=3.1.21.2; AltName: Full=Endodeoxyribonuclease IV; AltName: Full=Endonuclease IV; |
| Gene name | Name=nfo; |
Comments
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| FUNCTION | Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. |
| CATALYTIC ACTIVITY | Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end- products.; EC=3.1.21.2; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 3 Zn(2+) ions.; |
| SIMILARITY | Belongs to the AP endonuclease 2 family. |
Keywords
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Gene Ontology
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| GO:0008833; Molecular function:deoxyribonuclease IV (phage-T4-induced) activity |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0006281; Biological process:DNA repair |
Cross-references
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| Pfam | PF01261; AP_endonuc_2; 1; |
| NCBIfam | TIGR00587; Nfo; 1; |
| PROSITE | PS00729; AP_NUCLEASE_F2_1; 1; |
| PROSITE | PS00730; AP_NUCLEASE_F2_2; 1; |
| PROSITE | PS00731; AP_NUCLEASE_F2_3; 1; |
| PROSITE | PS51432; AP_NUCLEASE_F2_4; 1; |
Features
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| From: END4_ECOLI (P0A6C1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 69 | 69 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 109 | 109 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 145 | 145 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
E | ||||||||
| BINDING | 145 | 145 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
E | ||||||||
| BINDING | 179 | 179 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
D | ||||||||
| BINDING | 182 | 182 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="3" |
H | ||||||||
| BINDING | 216 | 216 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
| BINDING | 229 | 229 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="3" |
D | ||||||||
| BINDING | 231 | 231 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="3" |
H | ||||||||
| BINDING | 261 | 261 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
E | ||||||||
Additional information
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| Size range | 252-310 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |