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| Annotation rule MF_00152 |
General rule information
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| Accession | MF_00152 |
| Dates | 1-JUN-2001 (Created) 3-DEC-2019 (Last updated, Version 29) |
| Name | Nfo |
| Scope | Bacteria
Archaea |
| Template | P0A6C1 (END4_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. |
| Catalytic activity | Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.; EC=3.1.21.2; |
| Cofactor | Zn(2+) Note: Binds 3 Zn(2+) ions. |
| Similarity | Belongs to the AP endonuclease 2 family. |
Keywords
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Gene Ontology
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GO:0008833; Molecular function: deoxyribonuclease IV (phage-T4-induced) activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0006281; Biological process: DNA repair.
GO:0008270; Molecular function: zinc ion binding.
GO:0006281; Biological process: DNA repair.
Cross-references
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| Pfam | PF01261; AP_endonuc_2; 1; |
| TIGRFAMs | TIGR00587; Nfo; 1; |
| PROSITE | PS00729; AP_NUCLEASE_F2_1; 1; |
| PS00730; AP_NUCLEASE_F2_2; 1; | |
| PS00731; AP_NUCLEASE_F2_3; 1; | |
| PS51432; AP_NUCLEASE_F2_4; 1; |
Features
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| From: END4_ECOLI (P0A6C1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| METAL | 69 | 69 | Zinc 1 | H | ||||||||
| METAL | 109 | 109 | Zinc 1 | H | ||||||||
| METAL | 145 | 145 | Zinc 1 | E | ||||||||
| METAL | 145 | 145 | Zinc 2 | E | ||||||||
| METAL | 179 | 179 | Zinc 2 | D | ||||||||
| METAL | 182 | 182 | Zinc 3 | H | ||||||||
| METAL | 216 | 216 | Zinc 2 | H | ||||||||
| METAL | 229 | 229 | Zinc 3 | D | ||||||||
| METAL | 231 | 231 | Zinc 3 | H | ||||||||
| METAL | 261 | 261 | Zinc 2 | E | ||||||||
Additional information
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| Size range | 252-310 amino acids |
| Related rules | None |
| Fusion | None |