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| Annotation rule MF_00153 |
General rule information
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| Accession | MF_00153 |
| Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 29) |
| Name | DHS |
| Scope | Archaea |
| Templates | P49365 (DHYS_NEUCR); P38791 (DHYS_YEAST); P49366 (DHYS_HUMAN): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. |
| Catalytic activity | RHEA:33299: [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
EC 2.5.1.46 |
| Cofactor | NAD(+) |
| Pathway | Protein modification; eIF5A hypusination. |
| Similarity | Belongs to the deoxyhypusine synthase family. |
Keywords
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Gene Ontology
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GO:0034038; Molecular function: deoxyhypusine synthase activity.
Cross-references
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Features
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| From: DHYS_METJA (Q58224) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 303 | 303 | Nucleophile | K | ||||||||
Additional information
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| Size range | 292-345 amino acids |
| Related rules | MF_00640 (DHSL) |
| Fusion | None |
| Comments | Probable wrong start in many cases |