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Annotation rule MF_00153 |
Accession | MF_00153 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 29) |
Name | DHS |
Scope | Archaea |
Templates | P49365 (DHYS_NEUCR); P38791 (DHYS_YEAST); P49366 (DHYS_HUMAN): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. |
Catalytic activity | RHEA:33299: [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
EC 2.5.1.46 |
Cofactor | NAD(+) |
Pathway | Protein modification; eIF5A hypusination. |
Similarity | Belongs to the deoxyhypusine synthase family. |
From: DHYS_METJA (Q58224) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 303 | 303 | Nucleophile | K |
Size range | 292-345 amino acids |
Related rules | MF_00640 (DHSL) |
Fusion | None |
Comments | Probable wrong start in many cases |