HAMAP rule MF_00153
General rule information
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| Accession | MF_00153 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 30) |
| Name | DHS |
| Scope(s) |
Archaea |
| Template(s) | P49365 (DHYS_NEUCR); P38791 (DHYS_YEAST); P49366 (DHYS_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_00153 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DHYS |
| Protein name | RecName: Full=Probable deoxyhypusine synthase; Short=DHS; EC=2.5.1.46; |
| Gene name | Name=dys; |
Comments
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| FUNCTION | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. |
| CATALYTIC ACTIVITY | Reaction=[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]- deoxyhypusine + propane-1,3-diamine; Xref=Rhea:RHEA:33299, Rhea:RHEA- COMP:10143, Rhea:RHEA-COMP:10144, ChEBI:CHEBI:29969, ChEBI:CHEBI:57484, ChEBI:CHEBI:57834, ChEBI:CHEBI:82657; EC=2.5.1.46; |
| COFACTOR | Name=NAD(+); Xref=ChEBI:CHEBI:57540; |
| PATHWAY | Protein modification; eIF5A hypusination. |
| SIMILARITY | Belongs to the deoxyhypusine synthase family. |
Keywords
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Gene Ontology
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| GO:0034038; Molecular function:deoxyhypusine synthase activity |
Cross-references
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Features
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| From: DHYS_METJA (Q58224) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 303 | 303 | /note="Nucleophile" | K | ||||||||
Additional information
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| Size range | 292-345 amino acids |
| Related rules |
MF_00640 |
| Fusion | Nter: None Cter: None |
| Comments | Probable wrong start in many cases |