HAMAP rule MF_00153
General rule information
[?]
| Accession |
MF_00153 |
| Dates |
1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 30) |
Propagated annotation
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Identifier, protein and gene names
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| Protein name |
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RecName:
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Full=Probable deoxyhypusine synthase;
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Short=DHS;
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EC 2.5.1.46;
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| Function |
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. |
| Catalytic activity |
RHEA:33299: [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
EC 2.5.1.46
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| Cofactor |
NAD(+) |
| Pathway |
Protein modification; eIF5A hypusination. |
| Similarity |
Belongs to the deoxyhypusine synthase family. |
GO:0034038; Molecular function: deoxyhypusine synthase activity.
| From: DHYS_METJA (Q58224) |
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Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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303
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303
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Nucleophile
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K
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Additional information
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| Size range |
292-345 amino acids |
| Related rules |
MF_00640 (DHSL) |
| Fusion |
None |
| Comments |
Probable wrong start in many cases |
