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HAMAP rule MF_00153

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General rule information [?]

Accession MF_00153
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 30)
Name DHS
Templates P49365 (DHYS_NEUCR); P38791 (DHYS_YEAST); P49366 (DHYS_HUMAN): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Probable deoxyhypusine synthase;
Gene name

Comments [?]

Function Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Catalytic activity RHEA:33299: [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
Cofactor NAD(+)
Pathway Protein modification; eIF5A hypusination.
Similarity Belongs to the deoxyhypusine synthase family.

Keywords [?]

Gene Ontology [?]

GO:0034038; Molecular function: deoxyhypusine synthase activity.

Cross-references [?]

Pfam PF01916; DS; 1;
NCBIfam TIGR00321; Dhys; 1;

Features [?]

From: DHYS_METJA (Q58224)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     303     303       Nucleophile     K  

Additional information [?]

Size range 292-345 amino acids
Related rules MF_00640 (DHSL)
Fusion None
Comments Probable wrong start in many cases