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HAMAP rule MF_00153

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General rule information [?]

Accession MF_00153
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 30)
Name DHS
Scope(s) Archaea
Template(s) P49365 (DHYS_NEUCR); P38791 (DHYS_YEAST); P49366 (DHYS_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_00153 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DHYS
Protein name RecName: Full=Probable deoxyhypusine synthase;
Gene name Name=dys;

Comments [?]

FUNCTIONCatalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
CATALYTIC ACTIVITY Reaction=[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]- deoxyhypusine + propane-1,3-diamine; Xref=Rhea:RHEA:33299, Rhea:RHEA- COMP:10143, Rhea:RHEA-COMP:10144, ChEBI:CHEBI:29969, ChEBI:CHEBI:57484, ChEBI:CHEBI:57834, ChEBI:CHEBI:82657; EC=;
COFACTOR Name=NAD(+); Xref=ChEBI:CHEBI:57540;
PATHWAYProtein modification; eIF5A hypusination.
SIMILARITYBelongs to the deoxyhypusine synthase family.

Keywords [?]

Gene Ontology [?]

GO:0034038; Molecular function:deoxyhypusine synthase activity

Cross-references [?]

Pfam PF01916; DS; 1;
NCBIfam TIGR00321; Dhys; 1;

Features [?]

From: DHYS_METJA (Q58224)
Key From To Description Tag Condition FTGroup
ACT_SITE 303 303 /note="Nucleophile" K

Additional information [?]

Size range 292-345 amino acids
Related rules MF_00640
Fusion Nter: None Cter: None
Comments Probable wrong start in many cases

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