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Annotation rule MF_00154 |
General rule information
[?]
Accession |
MF_00154 |
Dates |
1-JUN-2001 (Created) 21-AUG-2020 (Last updated, Version 45) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Gammaproteobacteria>
else
end case
Protein name |
RecName:
|
Full=Protoheme IX farnesyltransferase;
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|
EC 2.5.1.141;
|
AltName:
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Full=Heme B farnesyltransferase;
|
AltName:
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Full=Heme O synthase;
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|
case <OC:Gammaproteobacteria>
else
end case
Function |
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. |
Catalytic activity |
RHEA:28070: (2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o
EC 2.5.1.141
|
Pathway |
Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. |
case <OC:Firmicutes> or <OC:Rhodobacterales>
Subunit |
Interacts with CtaA. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
Miscellaneous |
Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature. |
Similarity |
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0008495; Molecular function: protoheme IX farnesyltransferase activity.
GO:0048034; Biological process: heme O biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
General |
Transmembrane; -; 0-9; trigger=yes; |
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
From: CYOE_ECOLI (P0AEA5) |
Key
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From
|
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To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
TOPO_DOM
|
|
Nter
|
|
9
|
|
Cytoplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
10
|
|
28
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
29
|
|
37
|
|
Periplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
38
|
|
56
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
57
|
|
78
|
|
Cytoplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
79
|
|
97
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
98
|
|
107
|
|
Periplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
108
|
|
126
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
127
|
|
197
|
|
Cytoplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
198
|
|
216
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
217
|
|
228
|
|
Periplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
229
|
|
247
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
248
|
|
268
|
|
Cytoplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
269
|
|
287
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
288
|
|
Cter
|
|
Periplasmic
|
|
|
|
|
|
|
end case
Additional information
[?]
Size range |
259-345 amino acids |
Related rules |
None |
Fusion |
Nter: <Unknown>, <COX15-CtaA>; Cter: <Prenyltransferase> |
Comments |
Possible wrong start in RHOSH |