 |
|
| Annotation rule MF_00154 |
General rule information
[?]
| Accession | MF_00154 |
| Dates | 1-JUN-2001 (Created) 21-AUG-2020 (Last updated, Version 45) |
| Name | CyoE_CtaB |
| Scope | Bacteria
Archaea |
| Templates | P24009 (COXX2_BACSU); O31652 (COXX1_BACSU); P0AEA5 (CYOE_ECOLI); Q3J5F9 (COXX_RHOS4): [Recover all] |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Gammaproteobacteria>
| Identifier |
|
else
| Identifier |
|
end case
| Protein name |
|
||||||||||||||||
case <OC:Gammaproteobacteria>
| Gene name |
|
else
| Gene name |
|
end case
Comments
[?]
| Function | Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. |
| Catalytic activity | RHEA:28070: (2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o
EC 2.5.1.141 |
| Pathway | Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. |
case <OC:Firmicutes> or <OC:Rhodobacterales>
| Subunit | Interacts with CtaA. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
| Miscellaneous | Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature. |
| Similarity | Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. |
Keywords
[?]
case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
[?]
GO:0008495; Molecular function: protoheme IX farnesyltransferase activity.
GO:0048034; Biological process: heme O biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0048034; Biological process: heme O biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
[?]
| Pfam | PF01040; UbiA; 1; |
| PF02628; COX15-CtaA; 1; | |
| TIGRFAMs | TIGR01473; CyoE_ctaB; 1; |
| PROSITE | PS00943; UBIA; 1; |
Computed features
[?]
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
| General | Transmembrane; -; 0-9; trigger=yes; |
end case
Features
[?]
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
| From: CYOE_ECOLI (P0AEA5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 9 | Cytoplasmic | |||||||||
| TRANSMEM | 10 | 28 | Helical | |||||||||
| TOPO_DOM | 29 | 37 | Periplasmic | |||||||||
| TRANSMEM | 38 | 56 | Helical | |||||||||
| TOPO_DOM | 57 | 78 | Cytoplasmic | |||||||||
| TRANSMEM | 79 | 97 | Helical | |||||||||
| TOPO_DOM | 98 | 107 | Periplasmic | |||||||||
| TRANSMEM | 108 | 126 | Helical | |||||||||
| TOPO_DOM | 127 | 197 | Cytoplasmic | |||||||||
| TRANSMEM | 198 | 216 | Helical | |||||||||
| TOPO_DOM | 217 | 228 | Periplasmic | |||||||||
| TRANSMEM | 229 | 247 | Helical | |||||||||
| TOPO_DOM | 248 | 268 | Cytoplasmic | |||||||||
| TRANSMEM | 269 | 287 | Helical | |||||||||
| TOPO_DOM | 288 | Cter | Periplasmic | |||||||||
end case
Additional information
[?]
| Size range | 259-345 amino acids |
| Related rules | None |
| Fusion | Nter: <Unknown>, <COX15-CtaA>; Cter: <Prenyltransferase> |
| Comments | Possible wrong start in RHOSH |