HAMAP rule MF_00154
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00154 |
| Accession | MF_00154 |
| Dates | 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 49) |
| Name | CyoE_CtaB |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P24009 (COXX2_BACSU); O31652 (COXX1_BACSU); P0AEA5 (CYOE_ECOLI); Q3J5F9 (COXX_CERS4); [ Recover all ] |
| Triggered by |
HAMAP; MF_00154 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Gammaproteobacteria> | |
| Identifier | CYOE |
| else | |
| Identifier | COXX |
| end case | |
| Protein name | RecName: Full=Protoheme IX farnesyltransferase; EC=2.5.1.141; AltName: Full=Heme B farnesyltransferase; AltName: Full=Heme O synthase; |
| case <OC:Gammaproteobacteria> | |
| Gene name | Name=cyoE; |
| else | |
| Gene name | Name=ctaB; |
| end case | |
Comments
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| FUNCTION | Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. |
| CATALYTIC ACTIVITY | Reaction=heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377, ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530, ChEBI:CHEBI:175763; EC=2.5.1.141; |
| PATHWAY | Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. |
| case <OC:Bacillota> or <OC:Rhodobacterales> | |
| SUBUNIT | Interacts with CtaA. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| MISCELLANEOUS | Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature. |
| SIMILARITY | Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Heme biosynthesis | |
| Membrane | |
| Transferase | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0008495; Molecular function:protoheme IX farnesyltransferase activity |
| GO:0048034; Biological process:heme O biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01040; UbiA; 1; |
| Pfam | PF02628; COX15-CtaA; 1; |
| NCBIfam | TIGR01473; CyoE_ctaB; 1; |
| PROSITE | PS00943; UBIA; 1; |
| General | Transmembrane; -; 0-9; |
Features
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| From: CYOE_ECOLI (P0AEA5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | ||||||||||||
| TOPO_DOM | Nter | 9 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 10 | 28 | /note="Helical" | |||||||||
| TOPO_DOM | 29 | 37 | /note="Periplasmic" | |||||||||
| TRANSMEM | 38 | 56 | /note="Helical" | |||||||||
| TOPO_DOM | 57 | 78 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 79 | 97 | /note="Helical" | |||||||||
| TOPO_DOM | 98 | 107 | /note="Periplasmic" | |||||||||
| TRANSMEM | 108 | 126 | /note="Helical" | |||||||||
| TOPO_DOM | 127 | 197 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 198 | 216 | /note="Helical" | |||||||||
| TOPO_DOM | 217 | 228 | /note="Periplasmic" | |||||||||
| TRANSMEM | 229 | 247 | /note="Helical" | |||||||||
| TOPO_DOM | 248 | 268 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 269 | 287 | /note="Helical" | |||||||||
| TOPO_DOM | 288 | Cter | /note="Periplasmic" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 259-345 amino acids |
| Related rules |
None |
| Fusion | Nter: <Unknown>; <COX15-CtaA> Cter: <Prenyltransferase> |
| Comments | Possible wrong start in RHOSH |