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HAMAP rule MF_00154

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General rule information [?]

Accession MF_00154
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 48)
Name CyoE_CtaB
Scope(s) Bacteria
Template(s) P24009 (COXX2_BACSU); O31652 (COXX1_BACSU); P0AEA5 (CYOE_ECOLI); Q3J5F9 (COXX_CERS4); [ Recover all ]
Triggered by HAMAP; MF_00154 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Gammaproteobacteria>
Identifier CYOE
Identifier COXX
end case
Protein name RecName: Full=Protoheme IX farnesyltransferase;
AltName: Full=Heme B farnesyltransferase;
AltName: Full=Heme O synthase;
case <OC:Gammaproteobacteria>
Gene name Name=cyoE;
Gene name Name=ctaB;
end case

Comments [?]

FUNCTIONConverts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
CATALYTIC ACTIVITY Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377, ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530, ChEBI:CHEBI:175763; EC=;
PATHWAYPorphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.
case <OC:Bacillota> or <OC:Rhodobacterales>
SUBUNITInteracts with CtaA.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
MISCELLANEOUSCarbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
SIMILARITYBelongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Heme biosynthesis
Transmembrane helix

Gene Ontology [?]

GO:0008495; Molecular function:protoheme IX farnesyltransferase activity
GO:0048034; Biological process:heme O biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01040; UbiA; 1;
Pfam PF02628; COX15-CtaA; 1;
NCBIfam TIGR01473; CyoE_ctaB; 1;
General Transmembrane; -; 0-9;

Features [?]

Key From To Description Tag Condition FTGroup
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
TOPO_DOM Nter 9 /note="Cytoplasmic"
TRANSMEM 10 28 /note="Helical"
TOPO_DOM 29 37 /note="Periplasmic"
TRANSMEM 38 56 /note="Helical"
TOPO_DOM 57 78 /note="Cytoplasmic"
TRANSMEM 79 97 /note="Helical"
TOPO_DOM 98 107 /note="Periplasmic"
TRANSMEM 108 126 /note="Helical"
TOPO_DOM 127 197 /note="Cytoplasmic"
TRANSMEM 198 216 /note="Helical"
TOPO_DOM 217 228 /note="Periplasmic"
TRANSMEM 229 247 /note="Helical"
TOPO_DOM 248 268 /note="Cytoplasmic"
TRANSMEM 269 287 /note="Helical"
TOPO_DOM 288 Cter /note="Periplasmic"
end case

Additional information [?]

Size range 259-345 amino acids
Related rules None
Fusion Nter: <Unknown>; <COX15-CtaA> Cter: <Prenyltransferase>
Comments Possible wrong start in RHOSH

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