Home  |  Contact
Annotation rule MF_00154
Send feedback

General rule information [?]

Accession MF_00154
Dates 1-JUN-2001 (Created)
21-AUG-2020 (Last updated, Version 45)
Name CyoE_CtaB
Scope
Bacteria
Archaea
Templates P24009 (COXX2_BACSU); O31652 (COXX1_BACSU); P0AEA5 (CYOE_ECOLI); Q3J5F9 (COXX_RHOS4): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Gammaproteobacteria>
Identifier
CYOE
else
Identifier
COXX
end case
Protein name
RecName: Full=Protoheme IX farnesyltransferase;
EC 2.5.1.141;
AltName: Full=Heme B farnesyltransferase;
AltName: Full=Heme O synthase;
case <OC:Gammaproteobacteria>
Gene name
cyoE
else
Gene name
ctaB
end case

Comments [?]

Function Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Catalytic activity RHEA:28070: (2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o
EC 2.5.1.141
Pathway Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.
case <OC:Firmicutes> or <OC:Rhodobacterales>
Subunit Interacts with CtaA.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Miscellaneous Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Similarity Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0008495; Molecular function: protoheme IX farnesyltransferase activity.
GO:0048034; Biological process: heme O biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01040; UbiA; 1;
PF02628; COX15-CtaA; 1;
TIGRFAMs TIGR01473; CyoE_ctaB; 1;
PROSITE PS00943; UBIA; 1;

Computed features [?]

case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
General Transmembrane; -; 0-9; trigger=yes;
end case

Features [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
From: CYOE_ECOLI (P0AEA5)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     9       Cytoplasmic        
TRANSMEM     10     28       Helical        
TOPO_DOM     29     37       Periplasmic        
TRANSMEM     38     56       Helical        
TOPO_DOM     57     78       Cytoplasmic        
TRANSMEM     79     97       Helical        
TOPO_DOM     98     107       Periplasmic        
TRANSMEM     108     126       Helical        
TOPO_DOM     127     197       Cytoplasmic        
TRANSMEM     198     216       Helical        
TOPO_DOM     217     228       Periplasmic        
TRANSMEM     229     247       Helical        
TOPO_DOM     248     268       Cytoplasmic        
TRANSMEM     269     287       Helical        
TOPO_DOM     288     Cter       Periplasmic        
end case

Additional information [?]

Size range 259-345 amino acids
Related rules None
Fusion Nter: <Unknown>, <COX15-CtaA>; Cter: <Prenyltransferase>
Comments Possible wrong start in RHOSH