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HAMAP rule MF_00164

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General rule information [?]

Accession MF_00164
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 42)
Name GlmS
Scope(s) Bacteria
Template(s) P17169 (GLMS_ECOLI); Q56213 (GLMS_THET8); Q6LWM9 (GLMS_METMP); [ Recover all ]
Triggered by HAMAP; MF_00164 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GLMS
Protein name RecName: Full=Glutamine--fructose-6-phosphate aminotransferase [isomerizing];
AltName: Full=D-fructose-6-phosphate amidotransferase;
AltName: Full=GFAT;
AltName: Full=Glucosamine-6-phosphate synthase;
AltName: Full=Hexosephosphate aminotransferase;
AltName: Full=L-glutamine--D-fructose-6-phosphate amidotransferase;
Gene name Name=glmS;

Comments [?]

FUNCTIONCatalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
CATALYTIC ACTIVITY Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6- phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=;
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
case not <OG:Chloroplast>
end case

Keywords [?]

case not <OG:Chloroplast>
end case

Gene Ontology [?]

GO:0004360; Molecular function:glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0005975; Biological process:carbohydrate metabolic process
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case
case not <OG:Chloroplast>
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

Pfam PF00310; GATase_2; 1;
Pfam PF01380; SIS; 2;
NCBIfam TIGR01135; GlmS; 1;
PROSITE PS51464; SIS; 1-2;

Features [?]

From: GLMS_ECOLI (P17169)
Key From To Description Tag Condition FTGroup
INIT_MET 1 1 /note="Removed" M
ACT_SITE 2 2 /note="Nucleophile; for GATase activity" C
ACT_SITE 604 604 /note="For Fru-6P isomerization activity" K

Additional information [?]

Size range 589-635 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Nodulating bacteria seem to have two copies: a glmS and a nodM. There does not seem to be any mean of distinguishing the two forms. Intein deleted in METJA (not shown in alignment).

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