Home  |  Contact
Annotation rule MF_00164
Send feedback

General rule information [?]

Accession MF_00164
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 41)
Name GlmS
Templates P17169 (GLMS_ECOLI); Q56213 (GLMS_THET8); Q6LWM9 (GLMS_METMP): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Glutamine--fructose-6-phosphate aminotransferase [isomerizing];
AltName: Full=D-fructose-6-phosphate amidotransferase;
AltName: Full=GFAT;
AltName: Full=Glucosamine-6-phosphate synthase;
AltName: Full=Hexosephosphate aminotransferase;
AltName: Full=L-glutamine--D-fructose-6-phosphate amidotransferase;
Gene name

Comments [?]

Function Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
Catalytic activity RHEA:13237: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
Subunit Homodimer.
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
case not <OG:Chloroplast>
Subcellular location Cytoplasm.
end case

Keywords [?]

case not <OG:Chloroplast>
end case

Gene Ontology [?]

GO:0004360; Molecular function: glutamine-fructose-6-phosphate transaminase (isomerizing) activity.
GO:0005975; Biological process: carbohydrate metabolic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case
case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

Pfam PF00310; GATase_2; 1;
PF01380; SIS; 2; trigger=;
TIGRFAMs TIGR01135; GlmS; 1;
PROSITE PS51278; GATASE_TYPE_2; 1; trigger=PRU00609;
PS51464; SIS; 1-2; trigger=PRU00797;

Features [?]

From: GLMS_ECOLI (P17169)
Key     From     To       Description   Tag   Condition   FTGroup
INIT_MET     1     1       Removed     M  
ACT_SITE     2     2       Nucleophile; for GATase activity     C  
ACT_SITE     604     604       For Fru-6P isomerization activity     K  

Additional information [?]

Size range 589-635 amino acids
Related rules None
Fusion None
Comments Nodulating bacteria seem to have two copies: a glmS and a nodM. There does not seem to be any mean of distinguishing the two forms. Intein deleted in METJA (not shown in alignment).